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C4A-derived C4a [extracellular region]
Stable Identifier
R-HSA-166737
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C4A(680-756), Complement factor 4 fragment a
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Conversion of C4 into C4a and C4b (Homo sapiens)
C4a [extracellular region] (Homo sapiens)
C4A-derived C4a [extracellular region] (Homo sapiens)
General
C4 alpha chain has a thioester bond between Cys 1010 and Gln 1013
External Reference Information
External Reference
UniProt:P0C0L4 C4A
Gene Names
C4A, CO4, CPAMD2
Chain
signal peptide:1-19, chain:20-675, propeptide:676-679, chain:680-1446, chain:680-756, chain:757-1446, chain:957-1336, propeptide:1447-1453, chain:1454-1744
Reference Genes
BioGPS Gene:720 C4A
BioGPS Gene:721 C4A
COSMIC (genes):C4A C4A
CTD Gene:720 C4A
CTD Gene:721 C4A
dbSNP Gene:720 C4A
dbSNP Gene:721 C4A
ENSEMBL:ENSG00000244731 C4A
HGNC:1323 C4A
KEGG:hsa:720 C4A
KEGG:hsa:721 C4A
Monarch:720 C4A
Monarch:721 C4A
NCBI Gene:720 C4A
NCBI Gene:721 C4A
OMIM:120810 C4A
UCSC:P0C0L4 C4A
Reference Transcript
RefSeq:NM_007293.2 C4A
RefSeq:NM_001002029.3 C4A
RefSeq:NM_001252204.1 C4A
Other Identifiers
110384692
11734747_a_at
11749926_a_at
11754270_a_at
1559036_PM_at
1559036_at
17007048
17007118
17028176
17030967
17031045
17035749
17038462
17041030
17041111
208451_PM_s_at
208451_s_at
214428_PM_x_at
214428_x_at
235856_PM_at
235856_at
2902959
2902960
2902961
2902962
2902963
2902964
2902965
2902966
2902967
2902968
2902969
2902970
2902971
2902972
2902973
2902974
2902975
2902976
2902977
2902978
2902979
2902980
2902981
2902982
2902983
2902984
2902985
2902986
2902987
2902988
2902989
2902990
2902991
2902992
2902993
2902994
2902995
2902996
2902997
2902998
2902999
2903000
2903001
2903002
2903003
2903004
2903005
2903006
2903007
2903008
2903009
2903010
2903011
2903012
2903013
2903014
2903015
2903016
2903017
2903018
2903019
2903020
2903021
2903022
2903023
2903024
2903025
2903026
2903027
2903028
2903029
40766_at
720
74611_s_at
8118409
8118455
8179399
83226_at
A_14_P137370
A_23_P42282
GE61711
GE62331
GO:0001849
GO:0002376
GO:0004866
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005886
GO:0006954
GO:0006956
GO:0006958
GO:0030424
GO:0030425
GO:0042995
GO:0043025
GO:0043226
GO:0045087
GO:0045202
GO:0070062
GO:0072562
GO:0098542
GO:0098772
GO:2000427
HMNXSV003024675
Hs.150833.0.A1_3p_at
Hs2.150833.1.S1_3p_at
ILMN_1813695
ILMN_2179533
M59815_at
PH_hs_0031857
TC06002720.hg
TC06004079.hg
TC06004080.hg
TC6_cox_hap2000227.hg
TC6_dbb_hap3000078.hg
TC6_dbb_hap3000224.hg
TC6_mcf_hap5000068.hg
TC6_mcf_hap5000197.hg
TC6_qbl_hap6000208.hg
TC6_ssto_hap7000071.hg
TC6_ssto_hap7000201.hg
g5579450_3p_s_at
Participates
as a member of
C4a [extracellular region] (Homo sapiens)
Other forms of this molecule
dNQ-C4A(757-1446) [extracellular region]
C4A(1454-1744) [extracellular region]
C4A(20-675) [extracellular region]
S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) [extracellular region]
C4 alpha [extracellular region]
C4A(956-1336) [plasma membrane]
C4A alpha3 [extracellular region]
C4A alpha4 fragment [extracellular region]
C4A [endoplasmic reticulum lumen]
p-C4A [endoplasmic reticulum lumen]
Inferred To
c4a [extracellular region]
(Xenopus tropicalis)
C4A [extracellular region]
(Sus scrofa)
C4A-derived C4a [extracellular region]
(Bos taurus)
C4A-derived C4a [extracellular region]
(Gallus gallus)
C4b [extracellular region]
(Mus musculus)
C4b [extracellular region]
(Rattus norvegicus)
LOC481722 [extracellular region]
(Canis familiaris)
C4 [extracellular region]
(Rattus norvegicus)
Homologues of C4A-derived C4a [extracellular region]
(Bos taurus)
Homologues of C4A-derived C4a [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001239133.1
,
NP_001002029.3
,
NP_009224.2
OpenTargets
ENSG00000244731
ENSEMBL
ENSP00000396688
,
ENST00000421274
,
ENST00000428956
,
ENST00000498271
,
ENSP00000372815
,
ENSP00000420212
,
ENST00000383325
,
ENSP00000388662
HPA
ENSG00000244731-C4A
PRO
P0C0L4
Pharos - Targets
P0C0L4
Orphanet
C4A
GlyGen
P0C0L4
PDB
5JTW
,
5JPN
,
5JPM
,
1HZF
,
6YSQ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16625 OCLN
4
OCLN [plasma membrane]
(R-HSA-351846)
OCLN(321-522) [plasma membrane]
(R-HSA-351873)
OCLN(1-320) [plasma membrane]
(R-HSA-351854)
OCLN [cell junction]
(R-HSA-2160944)
0.527
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.527
2
UniProt:P46059 SLC15A1
1
SLC15A1 [plasma membrane]
(R-HSA-428022)
0.527
2
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