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deamidated-Q1013-C4A-derived C4b [extracellular region]
Stable Identifier
R-HSA-2855050
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Activation of C5 (Homo sapiens)
C5 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cleavage of C3 by C3 convertases (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Formation of classic pathway C5 convertase (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Initial triggering of complement (Homo sapiens)
C4b binds to cell surface (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C3 convertases spontaneously dissociate (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4b binding protein binds C4bC2a (Homo sapiens)
C4 binding protein:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
C4b binding protein displaces C2a (Homo sapiens)
C4 binding protein:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CD46 binds C4b (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CD55:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CR1 binds C3bBb/C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Displacement of C2a/Bb by CR1 (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C4bC2a [plasma membrane] (Homo sapiens)
Cell surface:C4b:C2a [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
Cell surface:C4b [plasma membrane] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Hydrolysis of internal thioester in C4b (Homo sapiens)
C4b with hydrolysed thioester [extracellular region] (Homo sapiens)
deamidated-Q1013-C4A-derived C4b [extracellular region] (Homo sapiens)
Participants
components
C4A(1454-1744) [extracellular region]
(Homo sapiens)
C4A(20-675) [extracellular region]
(Homo sapiens)
dNQ-C4A(757-1446) [extracellular region]
(Homo sapiens)
Participates
as a member of
C4b with hydrolysed thioester [extracellular region] (Homo sapiens)
C4b [extracellular region] (Homo sapiens)
Inferred To
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Bos taurus)
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Canis familiaris)
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Gallus gallus)
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Mus musculus)
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Rattus norvegicus)
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Sus scrofa)
deamidated-Q1013-C4A-derived C4b [extracellular region]
(Xenopus tropicalis)
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