Reactome | AKR1B10 [cytosol]

AKR1B10 [cytosol]

Stable Identifier

R-HSA-2855246

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aldo-keto reductase family 1 member B10 ecNumber1.1.1.-/ecNumber, AK1BA_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        Retinoid metabolism and transport (Homo sapiens)
        
        AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)
        
        AKRs [cytosol] (Homo sapiens)
        
        AKR1B10 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60218 AKR1B10

Gene Names

AKR1B10, AKR1B11

Chain

chain:1-316

Reference Genes

BioGPS Gene:57016 AKR1B10

COSMIC (genes):AKR1B10 AKR1B10

CTD Gene:57016 AKR1B10

dbSNP Gene:57016 AKR1B10

ENSEMBL:ENSG00000198074 AKR1B10

HGNC:382 AKR1B10

KEGG Gene (Homo sapiens):57016 AKR1B10

Monarch:57016 AKR1B10

NCBI Gene:57016 AKR1B10

OMIM:604707 AKR1B10

UCSC:O60218 AKR1B10

Reference Transcript

RefSeq:NM_020299.4 AKR1B10

Other Identifiers

0001050035

11724488_at

11724489_s_at

11724490_x_at

11742378_a_at

17051827

206561_s_at

3025434

3025435

3025436

3025439

3025442

3025445

3025447

3025449

3025451

3025453

3025454

3025455

3025456

3025457

3025471

3025478

3025480

3025482

3249535

3249536

3249537

3249540

3249541

37482_at

57016

8136336

A_23_P93641

GE61082

GO:0001523

GO:0001758

GO:0003674

GO:0004032

GO:0004033

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0006629

GO:0008106

GO:0008150

GO:0009056

GO:0016488

GO:0016491

GO:0019748

GO:0042572

GO:0043226

GO:0044281

GO:0044597

GO:0044598

GO:0045550

GO:0047655

GO:0047718

GO:0051186

GO:0052650

GO:0055114

GO:0110095

ILMN_1672148

PH_hs_0006395

TC07000834.hg

TC07002600.hg

g13346507_3p_s_at

Participant Of

hasMember

AKRs [cytosol]

Inferred To

akr1b1.1 [cytosol] (Danio rerio)

exc-15 [cytosol] (Caenorhabditis elegans)

AKR1E2 [cytosol] (Gallus gallus)

Akr1b10 [cytosol] (Mus musculus)

Dmel\CG6083 [cytosol] (Drosophila melanogaster)

Homologues of AKR1B10 [cytosol] (Caenorhabditis elegans)

Homologues of AKR1B10 [cytosol] (Danio rerio)

Homologues of AKR1B10 [cytosol] (Drosophila melanogaster)

Homologues of AKR1B10 [cytosol] (Gallus gallus)

akr1b1.2 [cytosol] (Danio rerio)

Akr1B [cytosol] (Drosophila melanogaster)

LOC418170 [cytosol] (Gallus gallus)

LOC100910708 [cytosol] (Rattus norvegicus)

LOC772271 [cytosol] (Gallus gallus)

AKR1B1 [cytosol] (Gallus gallus)

AKR1B10 [cytosol] (Bos taurus)

AKR1B10 [cytosol] (Caenorhabditis elegans)

AKR1B10 [cytosol] (Gallus gallus)

AKR1B10 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_064695.3

ZINC - World Drugs

AK1BA_HUMAN

OpenTargets

ENSG00000198074

ZINC - FDA approved

AK1BA_HUMAN

ZINC - Substances

AK1BA_HUMAN

ZINC - Biogenic

AK1BA_HUMAN

ZINC target

O60218

PRO

O60218

PDB

4GA8, 4WEV, 5M2F, 4XZL, 4GQG, 4ICC, 5LIU, 5LIY, 5Y7N, 4XZM, 4XZN, 1ZUA, 4I5X, 4JII, 4GAB, 5LIW, 4GQ0, 4JIH, 5LIX, 5LIK

ZINC - Investigational

AK1BA_HUMAN

ZINC - Metabolites

AK1BA_HUMAN

IntEnz

1.1.1.300

HPA

ENSG00000198074-AKR1B10

GeneCards

O60218

Ensembl

ENSG00000198074, ENST00000359579, ENSP00000352584

ZINC - Predictions - Purchasable

AK1BA_HUMAN

HMDB Protein

HMDBP11606

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.556	4