Reactome | Bradykinin receptors B1 and B2 bind to bradykinin

Bradykinin receptors B1 and B2 bind to bradykinin

Stable Identifier

R-HSA-374331

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Bradykinin receptors B1 and B2 bind to bradykinin

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Bradykinin (Rocha e Silva M, et al, 1949) is a 9 amino-acid peptide belonging to the kinin group of proteins. It causes blood vessel dilation via the release of prostacyclin, nitric oxide and endothelial-derived hyperpolarizing factor, resulting in lower blood pressure. It is also involved in the pain mechanism. Bradykinin exerts its effects through two receptors, bradykinin receptor B1 and 2 (B1R and B2R respectively). B1R (Menke JG et al, 1994) is synthesized de novo following tissue injury and receptor binding leads to an increase in cytosolic calcium concentration, resulting in chronic and acute inflammatory responses. Unlike B1R, B2R (Hess JF et al, 1992) is ubiquitously and constitutively expressed in healthy tissues. It also increase cytosolic calcium concentration and stimulates the mitogen-activated protein kinase pathways.

Literature References

PubMed ID	Title	Journal	Year
3366244	Isolation and identification of hydroxyproline analogues of bradykinin in human urine Kato, H, Matsumura, Y, Maeda, H	FEBS Lett	1988
8063797	Expression cloning of a human B1 bradykinin receptor Menke, JG, Borkowski, JA, Bierilo, KK, MacNeil, T, Derrick, AW, Schneck, KA, Ransom, RW, Strader, CD, Linemeyer, DL, Hess, JF	J Biol Chem	1994
1314587	Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor Hess, JF, Borkowski, JA, Young, GS, Strader, CD, Ransom, RW	Biochem Biophys Res Commun	1992
18127230	Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin ROCHA E SILVA, M, Beraldo, WT, ROSENFELD, G	Am J Physiol	1949