Bradykinin receptors B1 and B2 bind to bradykinin

Stable Identifier
R-HSA-374331
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Bradykinin (Rocha e Silva M, et al, 1949) is a 9 amino-acid peptide belonging to the kinin group of proteins. It causes blood vessel dilation via the release of prostacyclin, nitric oxide and endothelial-derived hyperpolarizing factor, resulting in lower blood pressure. It is also involved in the pain mechanism. Bradykinin exerts its effects through two receptors, bradykinin receptor B1 and 2 (B1R and B2R respectively). B1R (Menke JG et al, 1994) is synthesized de novo following tissue injury and receptor binding leads to an increase in cytosolic calcium concentration, resulting in chronic and acute inflammatory responses. Unlike B1R, B2R (Hess JF et al, 1992) is ubiquitously and constitutively expressed in healthy tissues. It also increase cytosolic calcium concentration and stimulates the mitogen-activated protein kinase pathways.

Literature References
PubMed ID Title Journal Year
8063797 Expression cloning of a human B1 bradykinin receptor

Menke, JG, Borkowski, JA, Bierilo, KK, MacNeil, T, Derrick, AW, Schneck, KA, Ransom, RW, Strader, CD, Linemeyer, DL, Hess, JF

J Biol Chem 1994
3366244 Isolation and identification of hydroxyproline analogues of bradykinin in human urine

Kato, H, Matsumura, Y, Maeda, H

FEBS Lett 1988
1314587 Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

Hess, JF, Borkowski, JA, Young, GS, Strader, CD, Ransom, RW

Biochem Biophys Res Commun 1992
18127230 Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin

ROCHA E SILVA, M, Beraldo, WT, ROSENFELD, G

Am J Physiol 1949
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