Reactome | CTSL2 [lysosomal lumen]

CTSL2 [lysosomal lumen]

Stable Identifier

R-HSA-1181232

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Cathepsin L2, CATL2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SERPINB13 binds cathepsin L (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL2 [lysosomal lumen] (Homo sapiens)
        
        SERPINB13:cathepsin L [lysosomal lumen] (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL2 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60911 CTSV

Gene Names

CTSV, CATL2, CTSL2, CTSU, UNQ268/PRO305

Chain

signal peptide:1-17, propeptide:18-113, chain:114-334

Reference Genes

BioGPS Gene:1515 CTSV

COSMIC (genes):CTSV CTSV

CTD Gene:1515 CTSV

dbSNP Gene:1515 CTSV

ENSEMBL:ENSG00000136943 CTSV

HGNC:2538 CTSV

KEGG:hsa:1515 CTSV

Monarch:1515 CTSV

NCBI Entrez Gene:1515 CTSV

OMIM:603308 CTSV

UCSC:O60911 CTSV

Reference Transcript

Other Identifiers

11748773_a_at

11748774_x_at

11755521_a_at

1515

17096285

210074_PM_at

210074_at

3170722

3178170

3178184

3205870

3216674

3216675

3216676

3216677

3216679

3216680

3216681

3216682

3216683

3216684

3216686

3216687

3216688

3216689

3216690

3216691

3216692

3216693

3216694

3216705

3216720

3216722

3216734

3216735

3287613

3288119

3409459

3799627

40717_at

8162652

A_21_P0013673

A_21_P0013703

A_23_P146456

GE53032

GE545996

GE794882

GO:0002376

GO:0004197

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0006508

GO:0008233

GO:0008234

GO:0016787

GO:0019886

GO:0022617

GO:0030198

GO:0043202

GO:0051603

HMNXSV003019892

Hs2.353110.1.S1_3p_at

Hs2.353110.1.S1_3p_x_at

ILMN_1748352

PH_hs_0031390

TC09001381.hg

g3228671_3p_at

p16864

Participates

as a candidate of

Cathepsin [lysosomal lumen] (Homo sapiens)

as a member of

Other forms of this molecule

CTSL2 [endolysosome lumen]

CTSL2 [extracellular region]

CTSL2 [early endosome lumen]

Inferred To

im:6910535 [lysosomal lumen] (Danio rerio)

FP3 [lysosomal lumen] (Plasmodium falciparum)

si:dkey-239j18.2 [lysosomal lumen] (Danio rerio)

FP2B [lysosomal lumen] (Plasmodium falciparum)

ctsl.1 [lysosomal lumen] (Danio rerio)

ctsl [lysosomal lumen] (Danio rerio)

cpl-1 [lysosomal lumen] (Caenorhabditis elegans)

Homologues of CTSL2 [lysosomal lumen] (Danio rerio)

Homologues of CTSL2 [lysosomal lumen] (Plasmodium falciparum)

CTSL2 [lysosomal lumen] (Bos taurus)

CTSL2 [lysosomal lumen] (Canis familiaris)

CTSL2 [lysosomal lumen] (Mus musculus)

CTSL2 [lysosomal lumen] (Plasmodium falciparum)

CTSL2 [lysosomal lumen] (Rattus norvegicus)

CTSL2 [lysosomal lumen] (Sus scrofa)

cprB [lysosomal lumen] (Dictyostelium discoideum)

FP2A [lysosomal lumen] (Plasmodium falciparum)

ctsv [lysosomal lumen] (Xenopus tropicalis)

CTSV [lysosomal lumen] (Gallus gallus)

CtsL1 [lysosomal lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_001188504.1, NP_001324.2

ZINC - World Drugs

CATL2_HUMAN

Guide to Pharmacology - Targets

2352

OpenTargets

ENSG00000136943

ENSEMBL

ENSP00000505681, ENST00000681737, ENST00000681927, ENSG00000136943, ENSP00000505141, ENST00000259470, ENSP00000506713, ENSP00000259470, ENST00000679661

ZINC - FDA approved

CATL2_HUMAN

ZINC - Substances

CATL2_HUMAN

ZINC - Biogenic

CATL2_HUMAN

ZINC target

O60911

PRO

O60911

GlyGen

O60911

PDB

7QGW, 7Q9H, 3KFQ, 3H6S, 7Q8N, 7Q8Q, 7Q8D, 7Q8O, 7Q8L, 7Q8J, 7Q8K, 1FH0, 7Q8M, 7QFH, 7QHJ, 7Q8H, 7QNS, 7Q8F, 7PK4, 7QHK, 7Q8I, 7QO2, 7Q8P, 7Q8G, 7QFF

ZINC - Investigational

CATL2_HUMAN

ZINC - Metabolites

CATL2_HUMAN

HPA

ENSG00000136943-CTSV

GeneCards

CTSV

Pharos - Targets

O60911

ZINC - Predictions - Purchasable

CATL2_HUMAN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07711 CTSL	9	CTSL(292-333) [endocytic vesicle lumen] (R-HSA-9686680) CTSL(114-288) [endocytic vesicle lumen] (R-HSA-9686686) CTSL(114-288) [endolysosome lumen] (R-HSA-1679050) CTSL(292-333) [endolysosome lumen] (R-HSA-1679026) CTSL1(114-288) [lysosomal lumen] (R-HSA-1181225) CTSL(292-333) [lysosomal lumen] (R-HSA-9935546) CTSL1(114-288) [early endosome lumen] (R-HSA-4127474) CTSL(292-333) [extracellular region] (R-HSA-449863) CTSL(114-288) [extracellular region] (R-HSA-449861)	0.723	4
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2
UniProt:Q9NYY3 PLK2	1	PLK2 [cytosol] (R-HSA-6801636)	0.527	2
UniProt:P43235 CTSK	3	CTSK [endolysosome lumen] (R-HSA-1678985) CTSK [extracellular region] (R-HSA-2470897) CTSK [lysosomal lumen] (R-HSA-1181226)	0.527	2
UniProt:P01042 KNG1	8	KNG1(19-380) [plasma membrane] (R-HSA-158245) KNG1(390-644) [plasma membrane] (R-HSA-158279) KNG1(19-644) [plasma membrane] (R-HSA-158269) KNG1(19-644) [extracellular region] (R-HSA-158125) KNG1(19-644) [platelet alpha granule lumen] (R-HSA-139864) p-KNG1 [endoplasmic reticulum lumen] (R-HSA-8956939) KNG1 [endoplasmic reticulum lumen] (R-HSA-8956767) Bradykinin [extracellular region] (R-HSA-158344)	0.527	2

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