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MMP3(100-477) [extracellular region]
Stable Identifier
R-HSA-1430778
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Matrix metalloproteinase-3, Stromelysin-1, MMP3_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Release of endostatin-like peptides (Homo sapiens)
Endostatin releasing proteases [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of MMP9 intermediate form by MMPs (Homo sapiens)
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Activation of proMMP7 by MMP3 (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Autocatalytic activation of MMP3 (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Full activation of MMP1 (Homo sapiens)
MMP2,3,7,10,11 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Initial activation of proMMP13 by MMP3 (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Initial activation of proMMP9 by MMPs (Homo sapiens)
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)
MMP1,2,3,7,9,12,13 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)
MMP1, 2, 3, 7,8,10,13,19 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)
MMP1,3,8,13, PRSS2 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
MMP2,3,4,9,10,12 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen type IX degradation by MMP3,13 (Homo sapiens)
MMP3,13 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen type VII degradation by MMP1,2,3 (Homo sapiens)
MMP1,2,3 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen type X degradation by MMP3, 13 (Homo sapiens)
MMP3,13 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)
MMP1,2,3,9 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Collagen type XVIII endostatin release (Homo sapiens)
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
MMP1-3, 7-9, 12, 13 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)
MMP2, MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
E-cadherin degradation by MMP3, MMP7 and plasmin (Homo sapiens)
MMP3, MMP7, Plasmin [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)
Elastin-degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)
MMP3, plasmin, (MMP12) [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)
Laminin-332 degrading extracellular proteinases [extracellular region] (Homo sapiens)
Laminin gamma-2 degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)
Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
NID1 degradation by MMP3, 7 (Homo sapiens)
MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)
MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
EGFR Transactivation by Gastrin (Homo sapiens)
Activated PKC-alpha activate MMP3 (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
MMPs cleave HB-EGF (Homo sapiens)
MMP2,3,7,9 [extracellular region] (Homo sapiens)
MMP3(100-477) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08254 MMP3
Gene Names
MMP3, STMY1
Chain
signal peptide:1-17, propeptide:18-99, chain:100-477
Reference Genes
BioGPS Gene:4314 MMP3
COSMIC (genes):MMP3 MMP3
CTD Gene:4314 MMP3
dbSNP Gene:4314 MMP3
ENSEMBL:ENSG00000149968 MMP3
HGNC:7173 MMP3
KEGG:hsa:4314 MMP3
Monarch:4314 MMP3
NCBI Gene:4314 MMP3
OMIM:185250 MMP3
UCSC:P08254 MMP3
Reference Transcript
RefSeq:NM_002422.4 MMP3
Other Identifiers
11723635_s_at
16743735
205828_PM_at
205828_at
3388802
3388839
3388840
3388842
3388843
3388844
3388845
3388846
3388847
3388848
3388849
3388850
3388852
3388853
3388854
3388855
3388856
3388857
3388858
4314
437_at
7951284
A_23_P161698
GE79854
GO:0002376
GO:0003824
GO:0004175
GO:0004222
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006508
GO:0008233
GO:0008237
GO:0008270
GO:0016787
GO:0022617
GO:0030163
GO:0030198
GO:0030312
GO:0030334
GO:0030574
GO:0031012
GO:0031334
GO:0034614
GO:0043226
GO:0045087
GO:0046872
GO:0051898
GO:0071222
GO:0071230
GO:0071492
GO:0071732
GO:0098542
GO:0140096
GO:0150077
GO:1904645
GO:2000378
HMNXSV003047826
ILMN_1784459
PH_hs_0024245
TC11002235.hg
TC11003313.hg
X05232_at
g13027803_3p_at
Participates
as an output of
Activated PKC-alpha activate MMP3 (Homo sapiens)
Autocatalytic activation of MMP3 (Homo sapiens)
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
MMP3, MMP7, Plasmin [extracellular region] (Homo sapiens)
MMP2,3,4,9,10,12 [extracellular region] (Homo sapiens)
MMP1-3, 7-9, 12, 13 [extracellular region] (Homo sapiens)
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
MMP2,3,7,10,11 [extracellular region] (Homo sapiens)
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP1,2,3,7,9,12,13 [extracellular region] (Homo sapiens)
MMP2, MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region] (Homo sapiens)
Laminin gamma-2 degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP1, 2, 3, 7,8,10,13,19 [extracellular region] (Homo sapiens)
MMP3, plasmin, (MMP12) [extracellular region] (Homo sapiens)
Elastin-degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP1,3,8,13, PRSS2 [extracellular region] (Homo sapiens)
MMP1,2,3,9 [extracellular region] (Homo sapiens)
MMP1,2,3 [extracellular region] (Homo sapiens)
MMP3,13 [extracellular region] (Homo sapiens)
as a candidate of
Endostatin releasing proteases [extracellular region] (Homo sapiens)
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
MMP2,3,7,9 [extracellular region] (Homo sapiens)
Other forms of this molecule
MMP3 [extracellular region]
MMP3(18-477) [extracellular region]
MMP3(55-477) [extracellular region]
MMP3(18-54) [extracellular region]
MMP3(55-99) [extracellular region]
Inferred To
Homologues of MMP3(100-477) [extracellular region]
(Caenorhabditis elegans)
Homologues of MMP3(100-477) [extracellular region]
(Drosophila melanogaster)
Homologues of MMP3(100-477) [extracellular region]
(Gallus gallus)
Homologues of MMP3(100-477) [extracellular region]
(Xenopus tropicalis)
Mmp3 [extracellular region]
(Mus musculus)
MMP3(100-477) [extracellular region]
(Bos taurus)
MMP3(100-477) [extracellular region]
(Caenorhabditis elegans)
MMP3(100-477) [extracellular region]
(Canis familiaris)
MMP3(100-477) [extracellular region]
(Danio rerio)
MMP3(100-477) [extracellular region]
(Drosophila melanogaster)
MMP3(100-477) [extracellular region]
(Gallus gallus)
MMP3(100-477) [extracellular region]
(Rattus norvegicus)
MMP3(100-477) [extracellular region]
(Sus scrofa)
MMP3(100-477) [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002413.1
Guide to Pharmacology - Targets
1630
OpenTargets
ENSG00000149968
ENSEMBL
ENSP00000299855
,
ENST00000299855
,
ENSG00000149968
ZINC - Substances
MMP3_HUMAN
ZINC - Biogenic
MMP3_HUMAN
ZINC target
P08254
PRO
P08254
PDB
1CIZ
,
1CAQ
,
1B3D
,
2SRT
,
1UEA
,
1C3I
,
1UMS
,
1UMT
,
1D8F
,
1SLM
,
3OHL
,
1HFS
,
1SLN
,
1D5J
,
7S7M
,
7S7L
,
4JA1
,
1HY7
,
1D7X
,
1D8M
,
1BQO
,
1C8T
,
1G4K
,
1QIC
,
1QIA
,
3USN
,
2JNP
,
1B8Y
,
1BM6
,
6N9D
,
3OHO
,
1G49
,
1CQR
,
1G05
,
2D1O
,
2JT6
,
2USN
,
2JT5
,
4G9L
,
4DPE
,
1OO9
,
6MAV
,
1BIW
,
1USN
ZINC - Investigational
MMP3_HUMAN
ZINC - Metabolites
MMP3_HUMAN
HPA
ENSG00000149968-MMP3
GeneCards
MMP3
Pharos - Targets
P08254
ZINC - Predictions - Purchasable
MMP3_HUMAN
HMDB Protein
HMDBP02592
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50222 MEOX2
0.556
3
UniProt:P09238 MMP10
2
MMP10(18-476) [extracellular region]
(R-HSA-1604748)
MMP10 [extracellular region]
(R-HSA-1442488)
0.527
3
UniProt:P02649 APOE
10
APOE [extracellular region]
(R-HSA-174646)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [plasma membrane]
(R-HSA-174615)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [endosome membrane]
(R-HSA-174766)
APOE [endosome lumen]
(R-HSA-174804)
APOE [early endosome]
(R-HSA-2429687)
0.527
2
UniProt:Q14766 LTBP1
3
p-LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8957050)
LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8956770)
LTBP1 [extracellular region]
(R-HSA-2161391)
0.527
2
UniProt:Q02818 NUCB1
2
p-NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8957027)
NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8956751)
0.527
2
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