Reactome | MMP3 [extracellular region]

MMP3 [extracellular region]

Stable Identifier

R-HSA-8943665

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Matrix metalloproteinase-3, Stromelysin-1, MMP3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
        
        EGFR Transactivation by Gastrin (Homo sapiens)
        
        Activated PKC-alpha activate MMP3 (Homo sapiens)
        
        MMP3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08254 MMP3

Gene Names

MMP3, STMY1

Chain

signal peptide:1-17, propeptide:18-99, chain:100-477

Reference Genes

BioGPS Gene:4314 MMP3

COSMIC (genes):MMP3 MMP3

CTD Gene:4314 MMP3

dbSNP Gene:4314 MMP3

ENSEMBL:ENSG00000149968 MMP3

ENSEMBL_homo_sapiens_GENE:ENSG00000149968.12 MMP3

HGNC:7173 MMP3

KEGG Gene (Homo sapiens):4314 MMP3

Monarch:4314 MMP3

NCBI Gene:4314 MMP3

OMIM:185250 MMP3

UCSC:P08254 MMP3

Reference Transcript

RefSeq:NM_002422.4 MMP3

Other Identifiers

11723635_s_at

16743735

205828_PM_at

205828_at

3388802

3388839

3388840

3388842

3388843

3388845

3388846

3388847

3388848

3388849

3388850

3388852

3388853

3388854

3388855

3388856

3388857

3388858

4314

437_at

7951284

A_23_P161698

GE79854

GO:0002376

GO:0003824

GO:0004175

GO:0004222

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0006508

GO:0006954

GO:0008233

GO:0008237

GO:0008270

GO:0016787

GO:0022617

GO:0030198

GO:0030312

GO:0030574

GO:0031012

GO:0031334

GO:0034614

GO:0043226

GO:0045087

GO:0046872

GO:0065003

GO:0071222

GO:0071492

GO:0071732

GO:0098542

GO:0140096

GO:0150077

GO:1904645

GO:2000378

HMNXSV003047826

ILMN_1784459

PH_hs_0024245

TC11002235.hg

TC11003313.hg

X05232_at

g13027803_3p_at

Participates

as an input of

Activated PKC-alpha activate MMP3 (Homo sapiens)

Other forms of this molecule

MMP3(55-99) [extracellular region]

MMP3(18-54) [extracellular region]

MMP3(55-477) [extracellular region]

MMP3(18-477) [extracellular region]

MMP3(100-477) [extracellular region]

Inferred To

MMP3 [extracellular region] (Bos taurus)

MMP3 [extracellular region] (Caenorhabditis elegans)

MMP3 [extracellular region] (Canis familiaris)

MMP3 [extracellular region] (Danio rerio)

MMP3 [extracellular region] (Drosophila melanogaster)

MMP3 [extracellular region] (Gallus gallus)

MMP3 [extracellular region] (Mus musculus)

MMP3 [extracellular region] (Rattus norvegicus)

MMP3 [extracellular region] (Sus scrofa)

MMP3 [extracellular region] (Xenopus tropicalis)

Homologues of MMP3 [extracellular region] (Caenorhabditis elegans)

Homologues of MMP3 [extracellular region] (Drosophila melanogaster)

Homologues of MMP3 [extracellular region] (Gallus gallus)

Homologues of MMP3 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002413.1

ZINC - World Drugs

MMP3_HUMAN

Guide to Pharmacology - Targets

1630

OpenTargets

ENSG00000149968

ZINC - Substances

MMP3_HUMAN

ZINC - Biogenic

MMP3_HUMAN

ZINC target

P08254

PRO

P08254

PDB

1UMS, 1USN, 6N9D, 1BM6, 6MAV, 1CQR, 1D8F, 3USN, 1CAQ, 2D1O, 1C3I, 2JT6, 4G9L, 1G49, 1D8M, 3OHL, 7S7L, 1B8Y, 1SLN, 1UMT, 1G05, 2USN, 2JNP, 1CIZ, 1QIA, 1SLM, 7S7M, 2SRT, 4JA1, 1HFS, 1BIW, 3OHO, 1QIC, 1B3D, 1D5J, 1BQO, 1HY7, 1UEA, 1D7X, 4DPE, 2JT5, 1OO9, 1G4K, 1C8T

ZINC - Investigational

MMP3_HUMAN

ZINC - Metabolites

MMP3_HUMAN

GeneCards

P08254

HPA

ENSG00000149968-MMP3

Ensembl

ENSG00000149968, ENSP00000299855, ENST00000299855

Pharos - Targets

P08254

ZINC - Predictions - Purchasable

MMP3_HUMAN

HMDB Protein

HMDBP02592

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50222 MEOX2			0.556	3
UniProt:Q02818 NUCB1	2	p-NUCB1 [endoplasmic reticulum lumen] (R-HSA-8957027) NUCB1 [endoplasmic reticulum lumen] (R-HSA-8956751)	0.527	2
UniProt:P09238 MMP10	2	MMP10(18-476) [extracellular region] (R-HSA-1604748) MMP10 [extracellular region] (R-HSA-1442488)	0.527	3
UniProt:Q14766 LTBP1	3	p-LTBP1 [endoplasmic reticulum lumen] (R-HSA-8957050) LTBP1 [endoplasmic reticulum lumen] (R-HSA-8956770) LTBP1 [extracellular region] (R-HSA-2161391)	0.527	2
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [extracellular region] (R-HSA-174646)	0.527	2

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