Reactome | Autocatalytic activation of MMP3

Autocatalytic activation of MMP3

Stable Identifier

R-HSA-1604731

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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After the initial cleavage of the N-terminus, MMP3 undergoes autocatalysis and cleavage of the His99-Phe100 bond (Nagase et al. 1990, 1991). Residue numbering given here is based on the UniProt canonical sequence.

Literature References

PubMed ID	Title	Journal	Year
2383557	Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate Nagase, H, Enghild, JJ, Suzuki, K, Salvesen, G	Biochemistry	1990
1783204	Substrate specificities and activation mechanisms of matrix metalloproteinases Nagase, H, Ogata, Y, Suzuki, K, Enghild, JJ, Salvesen, G	Biochem Soc Trans	1991