Autocatalytic activation of MMP3

Stable Identifier
R-HSA-1604731
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After the initial cleavage of the N-terminus, MMP3 undergoes autocatalysis and cleavage of the His99-Phe100 bond (Nagase et al. 1990, 1991). Residue numbering given here is based on the UniProt canonical sequence.

Literature References
PubMed ID Title Journal Year
1783204 Substrate specificities and activation mechanisms of matrix metalloproteinases

Nagase, H, Ogata, Y, Suzuki, K, Enghild, JJ, Salvesen, G

Biochem Soc Trans 1991
2383557 Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

Nagase, H, Enghild, JJ, Suzuki, K, Salvesen, G

Biochemistry 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP3(55-477) [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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