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MMP3(55-477) [extracellular region]
Stable Identifier
R-HSA-1604735
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MMP3 intermediate form, Matrix metalloproteinase-3, Stromelysin-1, MMP3_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Autocatalytic activation of MMP3 (Homo sapiens)
MMP3(55-477) [extracellular region] (Homo sapiens)
Initial activation of proMMP3 (Homo sapiens)
MMP3(55-477) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08254 MMP3
Gene Names
MMP3, STMY1
Chain
signal peptide:1-17, propeptide:18-99, chain:100-477
Reference Genes
BioGPS Gene:4314 MMP3
COSMIC (genes):MMP3 MMP3
CTD Gene:4314 MMP3
dbSNP Gene:4314 MMP3
ENSEMBL:ENSG00000149968 MMP3
HGNC:7173 MMP3
KEGG:hsa:4314 MMP3
Monarch:4314 MMP3
NCBI Gene:4314 MMP3
OMIM:185250 MMP3
UCSC:P08254 MMP3
Reference Transcript
RefSeq:NM_002422.4 MMP3
Other Identifiers
11723635_s_at
16743735
205828_PM_at
205828_at
3388802
3388839
3388840
3388842
3388843
3388844
3388845
3388846
3388847
3388848
3388849
3388850
3388852
3388853
3388854
3388855
3388856
3388857
3388858
4314
437_at
7951284
A_23_P161698
GE79854
GO:0002376
GO:0003824
GO:0004175
GO:0004222
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006508
GO:0008233
GO:0008237
GO:0008270
GO:0016787
GO:0022617
GO:0030163
GO:0030198
GO:0030312
GO:0030334
GO:0030574
GO:0031012
GO:0031334
GO:0034614
GO:0043226
GO:0045087
GO:0046872
GO:0051898
GO:0071222
GO:0071230
GO:0071492
GO:0071732
GO:0098542
GO:0140096
GO:0150077
GO:1904645
GO:2000378
HMNXSV003047826
ILMN_1784459
PH_hs_0024245
TC11002235.hg
TC11003313.hg
X05232_at
g13027803_3p_at
Participates
as an input of
Autocatalytic activation of MMP3 (Homo sapiens)
as an output of
Initial activation of proMMP3 (Homo sapiens)
Other forms of this molecule
MMP3(100-477) [extracellular region]
MMP3 [extracellular region]
MMP3(18-477) [extracellular region]
MMP3(18-54) [extracellular region]
MMP3(55-99) [extracellular region]
Inferred To
Homologues of MMP3(55-477) [extracellular region]
(Caenorhabditis elegans)
Homologues of MMP3(55-477) [extracellular region]
(Drosophila melanogaster)
Homologues of MMP3(55-477) [extracellular region]
(Gallus gallus)
Homologues of MMP3(55-477) [extracellular region]
(Xenopus tropicalis)
MMP3(55-477) [extracellular region]
(Bos taurus)
MMP3(55-477) [extracellular region]
(Caenorhabditis elegans)
MMP3(55-477) [extracellular region]
(Canis familiaris)
MMP3(55-477) [extracellular region]
(Danio rerio)
MMP3(55-477) [extracellular region]
(Drosophila melanogaster)
MMP3(55-477) [extracellular region]
(Gallus gallus)
MMP3(55-477) [extracellular region]
(Mus musculus)
MMP3(55-477) [extracellular region]
(Rattus norvegicus)
MMP3(55-477) [extracellular region]
(Sus scrofa)
MMP3(55-477) [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002413.1
ZINC - World Drugs
MMP3_HUMAN
Guide to Pharmacology - Targets
1630
OpenTargets
ENSG00000149968
ENSEMBL
ENSP00000299855
,
ENST00000299855
ZINC - Substances
MMP3_HUMAN
ZINC - Biogenic
MMP3_HUMAN
ZINC target
P08254
PRO
P08254
PDB
1CAQ
,
1UEA
,
1B3D
,
1CIZ
,
2SRT
,
1SLM
,
1D8F
,
1SLN
,
1D7X
,
1HY7
,
1HFS
,
1D5J
,
2D1O
,
1B8Y
,
1UMT
,
1UMS
,
1CQR
,
1C3I
,
3OHL
,
7S7L
,
7S7M
,
4JA1
,
1USN
,
4DPE
,
6MAV
,
4G9L
,
6N9D
,
2JT6
,
2JT5
,
3OHO
,
1BM6
,
1G49
,
2USN
,
1G05
,
1OO9
,
1D8M
,
1C8T
,
1G4K
,
1BQO
,
1BIW
,
2JNP
,
1QIA
,
3USN
,
1QIC
ZINC - Investigational
MMP3_HUMAN
ZINC - Metabolites
MMP3_HUMAN
HPA
ENSG00000149968-MMP3
Pharos - Targets
P08254
ZINC - Predictions - Purchasable
MMP3_HUMAN
HMDB Protein
HMDBP02592
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50222 MEOX2
0.556
3
UniProt:Q14766 LTBP1
3
p-LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8957050)
LTBP1 [endoplasmic reticulum lumen]
(R-HSA-8956770)
LTBP1 [extracellular region]
(R-HSA-2161391)
0.527
2
UniProt:P09238 MMP10
2
MMP10(18-476) [extracellular region]
(R-HSA-1604748)
MMP10 [extracellular region]
(R-HSA-1442488)
0.527
3
UniProt:P02649 APOE
10
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [extracellular region]
(R-HSA-174646)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [plasma membrane]
(R-HSA-174615)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [endosome membrane]
(R-HSA-174766)
APOE [endosome lumen]
(R-HSA-174804)
APOE [early endosome]
(R-HSA-2429687)
0.527
2
UniProt:Q02818 NUCB1
2
p-NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8957027)
NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8956751)
0.527
2
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