WWOX binds TFAP2C

Stable Identifier
R-HSA-8864569
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The tumor suppressor WWOX associates with TFAP2C (AP-2 gamma) in the cytosol and prevents TFAP2C nuclear translocation and TFAP2C-mediated transcription. WWOX is also able to bind to TFAP2A, but the biological role of this interaction has not been examined (Aqeilan et al. 2004). Low levels of WWOX and high levels of TFAP2C are associated with tamoxifen resistance in breast cancer (Guler et al. 2007).

Literature References
PubMed ID Title Journal Year
15548692 Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

Aqeilan, RI, Palamarchuk, A, Weigel, RJ, Herrero, JJ, Pekarsky, Y, Croce, CM

Cancer Res. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created