The tumor suppressor WWOX associates with TFAP2C (AP-2 gamma) in the cytosol and prevents TFAP2C nuclear translocation and TFAP2C-mediated transcription. WWOX is also able to bind to TFAP2A, but the biological role of this interaction has not been examined (Aqeilan et al. 2004). Low levels of WWOX and high levels of TFAP2C are associated with tamoxifen resistance in breast cancer (Guler et al. 2007).