WWOX binds ERBB4s80

Stable Identifier
R-HSA-1253343
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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WWOX binds to ERBB4s80 through WW-domain binding motifs in the C-tail of ERBB4. Formation of ERBB4s80:WWOX complex competes with the formation of ERBB4:YAP1 complex and prevents translocation of ERBB4s80 to the nucleus. Feng et al. established that WWOX binds with the same affinity to s80CYT1 and s80CYT2, and identified PY3 as the most important WW-domain binding motif for WWOX binding (Aqeilan et al. 2005, Feng et al. 2009, Schuchardt et al. 2013).

Literature References
PubMed ID Title Journal Year
16061658 WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

Aqeilan, RI, Donati, V, Palamarchuk, A, Trapasso, F, Kaou, M, Pekarsky, Y, Sudol, M, Croce, CM

Cancer Res 2005
19047365 The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation

Feng, SM, Muraoka-Cook, RS, Hunter, D, Sandahl, MA, Caskey, LS, Miyazawa, K, Atfi, A, Earp HS, 3rd

Mol Cell Biol 2009
24308844 Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase

Schuchardt, BJ, Bhat, V, Mikles, DC, McDonald, CB, Sudol, M, Farooq, A

Biochemistry 2013
Participants
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Orthologous Events
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