Displacement of DNA glycosylase by APEX1

Stable Identifier
R-HSA-110357
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Displacement of DNA glycosylase by APEX1
Click the image above or here to open this pathway in the Pathway Browser

Following cleavage of the damaged base, DNA glycosylase is displaced by APEX1, an AP endonuclease (Parikh et al. 1998).

Literature References
PubMed ID Title Journal Year
9724657 Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

Parikh, SS, Mol, CD, Slupphaug, G, Bharati, S, Krokan, HE, Tainer, JA

EMBO J 1998
Participants
Events
Participant Of
hasEvent
Orthologous Events
Displacement of DNA glycosylase by APEX1 (Caenorhabditis elegans)
Displacement of DNA glycosylase by APEX1 (Canis familiaris)
Displacement of DNA glycosylase by APEX1 (Danio rerio)
Displacement of DNA glycosylase by APEX1 (Dictyostelium discoideum)
Displacement of DNA glycosylase by APEX1 (Drosophila melanogaster)
Displacement of DNA glycosylase by APEX1 (Mus musculus)
Displacement of DNA glycosylase by APEX1 (Plasmodium falciparum)
Displacement of DNA glycosylase by APEX1 (Rattus norvegicus)
Displacement of DNA glycosylase by APEX1 (Sus scrofa)
Displacement of DNA glycosylase by APEX1 (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)