Reactome | Displacement of MUTYH glycosylase by APEX1 at the AP site

Displacement of MUTYH glycosylase by APEX1 at the AP site

Stable Identifier

R-HSA-110355

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic site lyase, displaces MUTYH (MYH) from the AP site generated by the MUTYH DNA glycosylase activity, thus increasing MUTYH turnover and overall glycosylase efficiency, and allowing for the base excision repair to proceed (Yang et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11160897	Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch	Nucleic Acids Res.	2001

Participants

Input

Output

Participant Of

hasEvent

Displacement of DNA glycosylase by APEX1

Orthologous Events

Displacement of MUTYH glycosylase by APEX1 at the AP site (Arabidopsis thaliana)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Oryza sativa)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Taeniopygia guttata)

Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)