Displacement of MUTYH glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110355
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Displacement of MUTYH glycosylase by APEX1 at the AP site
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic site lyase, displaces MUTYH (MYH) from the AP site generated by the MUTYH DNA glycosylase activity, thus increasing MUTYH turnover and overall glycosylase efficiency, and allowing for the base excision repair to proceed (Yang et al. 2001).

Literature References
PubMed ID Title Journal Year
11160897 Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

Yang, H, Clendenin, WM, Wong, D, Demple, B, Slupska, MM, Chiang, JH, Miller, JH

Nucleic Acids Res. 2001
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Orthologous Events
Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)