Displacement of TDG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Displacement of TDG glycosylase by APEX1 at the AP site
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces TDG from the AP site created by the DNA glycosylase activity of TDG. In the absence of APEX1, TDG remains tightly bound to the AP site, which inhibits subsequent steps in the base excision repair. Sumoylation of TDG may also be involved in the APEX1-mediated displacement of TDG from AP sites (Hardeland et al. 2002, Steinacher and Schar 2005, Fitzgerald and Drohat 2008).
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Orthologous Events
Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)
Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)
Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)
Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of TDG glycosylase by APEX1 at the AP site (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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