Displacement of MPG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110356
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces MPG from the AP site generated by the MPG DNA glycosylase activity, thus increasing MPG turnover and the overall glycosylase efficiency (Xia et al. 2005).

Participants
Participant Of
Orthologous Events