Displacement of MPG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110356
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces MPG from the AP site generated by the MPG DNA glycosylase activity, thus increasing MPG turnover and the overall glycosylase efficiency (Xia et al. 2005).

Literature References
PubMed ID Title Journal Year
15713479 Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease

Xia, L, Zheng, L, Lee, HW, Bates, SE, Federico, L, Shen, B, O'Connor, TR

J. Mol. Biol. 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Displacement of MPG glycosylase by APEX1 at the AP site (Arabidopsis thaliana)
Displacement of MPG glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)
Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)
Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of MPG glycosylase by APEX1 at the AP site (Oryza sativa)
Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)
Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of MPG glycosylase by APEX1 at the AP site (Taeniopygia guttata)
Displacement of MPG glycosylase by APEX1 at the AP site (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)