Displacement of MPG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110356
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Displacement of MPG glycosylase by APEX1 at the AP site
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces MPG from the AP site generated by the MPG DNA glycosylase activity, thus increasing MPG turnover and the overall glycosylase efficiency (Xia et al. 2005).
Literature References
PubMed ID Title Journal Year
15713479 Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease

Xia, L, Bates, SE, O'Connor, TR, Zheng, L, Federico, L, Lee, HW, Shen, B

J. Mol. Biol. 2005
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Orthologous Events
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Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)
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Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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