Displacement of MPG glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110356
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Displacement of MPG glycosylase by APEX1 at the AP site
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces MPG from the AP site generated by the MPG DNA glycosylase activity, thus increasing MPG turnover and the overall glycosylase efficiency (Xia et al. 2005).

Literature References
PubMed ID Title Journal Year
15713479 Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease

Xia, L, Zheng, L, Lee, HW, Bates, SE, Federico, L, Shen, B, O'Connor, TR

J. Mol. Biol. 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)
Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)
Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)
Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of MPG glycosylase by APEX1 at the AP site (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)