Displacement of SMUG1 glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110351
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Displacement of SMUG1 glycosylase by APEX1 at the AP site
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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces SMUG1 from the AP site created by the SMUG1 DNA glycosylase activity (Pettersen et al. 2007).
Literature References
PubMed ID Title Journal Year
17537817 Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

Kavli, B, Pettersen, HS, Slupphaug, G, Krokan, HE, Sundheim, O, Gilljam, KM

Nucleic Acids Res. 2007
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Orthologous Events
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Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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