Displacement of NTHL1 glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110352
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces NTHL1 (hNTH1) from the AP site generated by the NTHL1 DNA glycosylase activity. Current data indicate that while the NTHL1 DNA lyase activity is blocked at most NTHL1-bound AP sites, it can act on the AP site generated by the thymine glycol cleavage (Marenstein et al. 2003).

Literature References
PubMed ID Title Journal Year
12519758 Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity

Marenstein, DR, Chan, MK, Altamirano, A, Basu, AK, Boorstein, RJ, Cunningham, RP, Teebor, GW

J. Biol. Chem. 2003
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Orthologous Events
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Arabidopsis thaliana)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Caenorhabditis elegans)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Canis familiaris)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Danio rerio)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Saccharomyces cerevisiae)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Taeniopygia guttata)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)