Reactome | Displacement of NTHL1 glycosylase by APEX1 at the AP site

Displacement of NTHL1 glycosylase by APEX1 at the AP site

Stable Identifier

R-HSA-110352

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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Displacement of NTHL1 glycosylase by APEX1 at the AP site

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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces NTHL1 (hNTH1) from the AP site generated by the NTHL1 DNA glycosylase activity. Current data indicate that while the NTHL1 DNA lyase activity is blocked at most NTHL1-bound AP sites, it can act on the AP site generated by the thymine glycol cleavage (Marenstein et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12519758	Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity Marenstein, DR, Chan, MK, Altamirano, A, Basu, AK, Boorstein, RJ, Cunningham, RP, Teebor, GW	J. Biol. Chem.	2003