Displacement of NTHL1 glycosylase by APEX1 at the AP site

Stable Identifier
R-HSA-110352
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces NTHL1 (hNTH1) from the AP site generated by the NTHL1 DNA glycosylase activity. Current data indicate that while the NTHL1 DNA lyase activity is blocked at most NTHL1-bound AP sites, it can act on the AP site generated by the thymine glycol cleavage (Marenstein et al. 2003).

Literature References
PubMed ID Title Journal Year
12519758 Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity

Marenstein, DR, Chan, MK, Altamirano, A, Basu, AK, Boorstein, RJ, Cunningham, RP, Teebor, GW

J. Biol. Chem. 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed