Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LIG3:XRCC1 [nucleoplasm]
Stable Identifier
R-HSA-110338
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Resolution of AP sites via the single-nucleotide replacement pathway (Homo sapiens)
Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Resynthesis of excised residue by POLB (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8978692
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
Lindahl, T
,
Kubota, Y
,
Nash, RA
,
Klungland, A
,
Schär, P
,
Barnes, DE
EMBO J
1997
Participants
components
LIG3 [nucleoplasm]
(Homo sapiens)
XRCC1 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
as a component of
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Homo sapiens)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
as an input of
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
as a member of
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Inferred To
LIG3:XRCC1 [nucleoplasm]
(Bos taurus)
LIG3:XRCC1 [nucleoplasm]
(Canis familiaris)
LIG3:XRCC1 [nucleoplasm]
(Danio rerio)
LIG3:XRCC1 [nucleoplasm]
(Dictyostelium discoideum)
LIG3:XRCC1 [nucleoplasm]
(Drosophila melanogaster)
LIG3:XRCC1 [nucleoplasm]
(Gallus gallus)
LIG3:XRCC1 [nucleoplasm]
(Mus musculus)
LIG3:XRCC1 [nucleoplasm]
(Rattus norvegicus)
LIG3:XRCC1 [nucleoplasm]
(Sus scrofa)
LIG3:XRCC1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-793
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text