MRN recruits LIG3:XRCC1 to MMEJ sites

Stable Identifier
R-HSA-5687673
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MRN recruits LIG3:XRCC1 to MMEJ sites
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The MRN complex recruits DNA ligase 3 (LIG3) bound to XRCC1 (LIG3:XRCC1) to microhomology-mediated end joining (MMEJ) sites through direct interactions of the MRN subunits RAD50 and NBN (NBS1) with LIG3 (Della-Maria et al. 2011).
Literature References
PubMed ID Title Journal Year
21816818 Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway

Tsai, MS, Kuhnlein, J, Zhou, Y, Della-Maria, J, Carney, JP, Tomkinson, AE, Paull, TT

J. Biol. Chem. 2011
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Orthologous Events
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MRN recruits LIG3:XRCC1 to MMEJ sites (Gallus gallus)
MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)
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MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-08)
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