MRN recruits LIG3:XRCC1 to MMEJ sites

Stable Identifier
R-HSA-5687673
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The MRN complex recruits DNA ligase 3 (LIG3) bound to XRCC1 (LIG3:XRCC1) to microhomology-mediated end joining (MMEJ) sites through direct interactions of the MRN subunits RAD50 and NBN (NBS1) with LIG3 (Della-Maria et al. 2011).

Literature References
PubMed ID Title Journal Year
21816818 Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway

Della-Maria, J, Zhou, Y, Tsai, MS, Kuhnlein, J, Carney, JP, Paull, TT, Tomkinson, AE

J. Biol. Chem. 2011
Participants
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Orthologous Events
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