Recruitment of LIG3:XRCC1 complex to the site of repair by POLB

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After abasic (AP) residue (5'dRP) is excised by POLB, which is accompanied by dissociation of APEX1 from the DNA, POLB recruits XRCC1:LIG3 complex, consisting of DNA repair protein XRCC1 and DNA ligase 3, to the DNA containing a single nucleotide gap (Nazarkina et al. 2007). The N-terminus of XRCC1 interacts with POLB, while the C-terminus of XRCC1 interacts with LIG3 (Kubota et al. 1996).

Literature References
PubMed ID Title Journal Year
8978692 Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE, Lindahl, T

EMBO J 1997
17118717 XRCC1 interactions with base excision repair DNA intermediates

Nazarkina, ZK, Khodyreva, SN, Marsin, S, Lavrik, OI, Radicella, JP

DNA Repair (Amst.) 2007
Participant Of
Orthologous Events
Cite Us!