Reactome | Recruitment of LIG3:XRCC1 complex to the site of repair by POLB

Recruitment of LIG3:XRCC1 complex to the site of repair by POLB

Stable Identifier

R-HSA-110376

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Recruitment of LIG3:XRCC1 complex to the site of repair by POLB

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After abasic (AP) residue (5'dRP) is excised by POLB, which is accompanied by dissociation of APEX1 from the DNA, POLB recruits XRCC1:LIG3 complex, consisting of DNA repair protein XRCC1 and DNA ligase 3, to the DNA containing a single nucleotide gap (Nazarkina et al. 2007). The N-terminus of XRCC1 interacts with POLB, while the C-terminus of XRCC1 interacts with LIG3 (Kubota et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
17118717	XRCC1 interactions with base excision repair DNA intermediates Radicella, JP, Marsin, S, Nazarkina, ZK, Khodyreva, SN, Lavrik, OI	DNA Repair (Amst.)	2007
8978692	Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. Lindahl, T, Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE	EMBO J	1997