Recruitment of LIG3:XRCC1 complex to the site of repair by POLB

Stable Identifier
R-HSA-110376
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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After abasic (AP) residue (5'dRP) is excised by POLB, which is accompanied by dissociation of APEX1 from the DNA, POLB recruits XRCC1:LIG3 complex, consisting of DNA repair protein XRCC1 and DNA ligase 3, to the DNA containing a single nucleotide gap (Nazarkina et al. 2007). The N-terminus of XRCC1 interacts with POLB, while the C-terminus of XRCC1 interacts with LIG3 (Kubota et al. 1996).

Literature References
PubMed ID Title Journal Year
8978692 Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE, Lindahl, T

EMBO J 1997
17118717 XRCC1 interactions with base excision repair DNA intermediates

Nazarkina, ZK, Khodyreva, SN, Marsin, S, Lavrik, OI, Radicella, JP

DNA Repair (Amst.) 2007
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