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Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
Stable Identifier
R-HSA-5687677
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21816818
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway
Tsai, MS
,
Kuhnlein, J
,
Zhou, Y
,
Della-Maria, J
,
Carney, JP
,
Tomkinson, AE
,
Paull, TT
J. Biol. Chem.
2011
Participants
components
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm]
(Homo sapiens)
LIG3:XRCC1 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
as an output of
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
Inferred To
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Bos taurus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Gallus gallus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Rattus norvegicus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
(Sus scrofa)
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