Reactome | FUT8 [Golgi membrane]

FUT8 [Golgi membrane]

Stable Identifier

R-HSA-1028782

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-1,6-fucosyltransferase 8, FUT8_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike trimer glycoside chains get additional branches (Homo sapiens)
        
        FUT8 [Golgi membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)
        
        FUT8 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYC5 FUT8

Gene Names

FUT8

Chain

chain:1-575

Reference Genes

BioGPS Gene:2530 FUT8

COSMIC (genes):FUT8 FUT8

CTD Gene:2530 FUT8

dbSNP Gene:2530 FUT8

ENSEMBL:ENSG00000033170 FUT8

ENSEMBL_homo_sapiens_GENE:ENSG00000033170.17 FUT8

HGNC:4019 FUT8

KEGG Gene (Homo sapiens):2530 FUT8

Monarch:2530 FUT8

NCBI Gene:2530 FUT8

OMIM:602589 FUT8

UCSC:Q9BYC5 FUT8

Reference Transcript

Other Identifiers

11741568_a_at

11749723_a_at

1554930_PM_a_at

1554930_a_at

16785483

203988_PM_s_at

203988_s_at

2530

3540553

3540554

3540555

3540561

3540572

3540573

3540574

3540575

3540585

3540586

3540592

3540605

3540606

3540614

3540616

3540618

3540623

3540624

3540625

3540626

3540627

3540628

41628_at

42282_at

7975136

A_14_P109106

A_14_P113075

A_23_P313632

D89289_at

GE60337

GO:0000139

GO:0001701

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0005975

GO:0006486

GO:0006487

GO:0006491

GO:0007179

GO:0007229

GO:0007585

GO:0008424

GO:0009312

GO:0010468

GO:0010761

GO:0016020

GO:0016477

GO:0016740

GO:0016757

GO:0016758

GO:0017124

GO:0018279

GO:0019082

GO:0023052

GO:0032580

GO:0036071

GO:0036211

GO:0042355

GO:0043112

GO:0043226

GO:0046368

GO:0046921

GO:0048856

GO:0048870

GO:0055086

GO:0070062

GO:0140096

GO:1900407

GO:1901135

HMNXSV003010961

Hs2.118722.3.S1_3p_s_at

ILMN_1741422

PH_hs_0006549

TC14000397.hg

TC14001735.hg

g4758407_3p_a_at

p33676

Inferred To

FUT8 [Golgi membrane] (Bos taurus)

FUT8 [Golgi membrane] (Canis familiaris)

FUT8 [Golgi membrane] (Gallus gallus)

FUT8 [Golgi membrane] (Sus scrofa)

FucT6 [Golgi membrane] (Drosophila melanogaster)

Fut8 [Golgi membrane] (Mus musculus)

Fut8 [Golgi membrane] (Rattus norvegicus)

fut-8 [Golgi membrane] (Caenorhabditis elegans)

fut8 [Golgi membrane] (Xenopus tropicalis)

fut8a [Golgi membrane] (Danio rerio)

Cross References

RefSeq

NP_004471.4, NP_835369.1, NP_835368.1

OpenTargets

ENSG00000033170

HPA

ENSG00000033170-FUT8

GeneCards

Q9BYC5

Ensembl

ENST00000673929, ENSP00000345865, ENST00000360689, ENSP00000353910, ENSP00000378087, ENSP00000501213, ENSG00000033170, ENST00000394586, ENST00000557164, ENSP00000452433, ENST00000342677

PRO

Q9BYC5

Pharos - Targets

Q9BYC5

HMDB Protein

HMDBP05922

PDB

6X5H, 6VLD, 6X5T, 6X5R, 6X5U, 6X5S, 6VLE, 2DE0

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DT7-3 ZBTB10			0.556	3
UniProt:Q3MIR4 CC50B			0.527	2
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.527	2
UniProt:O14764 GBRD			0.527	3
UniProt:P08842 STS	3	STS [endoplasmic reticulum lumen] (R-HSA-1614318) OxA-STS [endoplasmic reticulum lumen] (R-HSA-1614333) OxA-STS [endoplasmic reticulum membrane] (R-HSA-1606833)	0.527	2
UniProt:Q92581 SLC9A6	6	SLC9A6 E255_S256del [early endosome membrane] (R-HSA-5661066) SLC9A6 E547* [early endosome membrane] (R-HSA-5661037) SLC9A6 R468* [early endosome membrane] (R-HSA-5661072) SLC9A6 338-340del [early endosome membrane] (R-HSA-5661042) SLC9A6 H171fs*60 [early endosome membrane] (R-HSA-5661079) SLC9A6 [early endosome membrane] (R-HSA-425984)	0.527	4
UniProt:Q9BX97 PLVAP			0.527	2
UniProt:Q14314 FGL2	2	FGL2 [extracellular region] (R-HSA-6801586) FGL2 [ficolin-1-rich granule lumen] (R-HSA-6801499)	0.527	2
UniProt:O75752 B3GALNT1	1	B3GALNT1 [Golgi membrane] (R-HSA-8878918)	0.527	2
UniProt:P26572 MGAT1	1	MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-964750)	0.527	3
UniProt:Q16706 MAN2A1	2	MAN2A1 [transport vesicle] (R-HSA-8847487) MAN2A1 [Golgi membrane] (R-HSA-975823)	0.527	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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