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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
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Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
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FAQ
Linking to Us
Citing us
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Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
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Search ...
Go!
Hist [extracellular region]
Stable Identifier
R-ALL-390899
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
histamine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
AOC1 deaminates Hist (Bos taurus)
Hist [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
G alpha (q) signalling events (Bos taurus)
The Ligand:GPCR:Gq complex dissociates (Bos taurus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
Hist [extracellular region]
G alpha (s) signalling events (Bos taurus)
Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
HRH2:histamine [plasma membrane] (Bos taurus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
HRH2:histamine [plasma membrane] (Bos taurus)
Hist [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Amine ligand-binding receptors (Bos taurus)
Histamine receptors (Bos taurus)
HRH2 binds hist (Bos taurus)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Bos taurus)
Hist [extracellular region]
HRH3 binds Hist (Bos taurus)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
HRH4 binds Hist (Bos taurus)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Bos taurus)
Hist [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Organic cation/anion/zwitterion transport (Bos taurus)
Organic cation transport (Bos taurus)
OCT1 transports organic cations into hepatic cells (Bos taurus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Bos taurus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
G alpha (q) signalling events (Caenorhabditis elegans)
The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
Hist [extracellular region]
G alpha (s) signalling events (Caenorhabditis elegans)
Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Caenorhabditis elegans)
HRH2:histamine [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Caenorhabditis elegans)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Caenorhabditis elegans)
HRH2:histamine [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
GPCR ligand binding (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Amine ligand-binding receptors (Caenorhabditis elegans)
Histamine receptors (Caenorhabditis elegans)
HRH2 binds hist (Caenorhabditis elegans)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
HRH3 binds Hist (Caenorhabditis elegans)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
HRH4 binds Hist (Caenorhabditis elegans)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
Hist [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic cation transport (Caenorhabditis elegans)
OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
AOC1 deaminates Hist (Canis familiaris)
Hist [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
G alpha (q) signalling events (Canis familiaris)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
HRH1:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
HRH1:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
HRH1:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
HRH1:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
HRH1:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
Hist [extracellular region]
G alpha (s) signalling events (Canis familiaris)
Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
HRH2:histamine [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Canis familiaris)
HRH2:histamine [plasma membrane] (Canis familiaris)
Hist [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Amine ligand-binding receptors (Canis familiaris)
Histamine receptors (Canis familiaris)
HRH1 binds hist (Canis familiaris)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
HRH2 binds hist (Canis familiaris)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Canis familiaris)
Hist [extracellular region]
HRH3 binds Hist (Canis familiaris)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
HRH4 binds Hist (Canis familiaris)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Canis familiaris)
Hist [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic cation transport (Canis familiaris)
OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
AOC1 deaminates Hist (Danio rerio)
Hist [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
G alpha (q) signalling events (Danio rerio)
The Ligand:GPCR:Gq complex dissociates (Danio rerio)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Danio rerio)
Hist [extracellular region]
G alpha (s) signalling events (Danio rerio)
Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
HRH2:histamine [plasma membrane] (Danio rerio)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Danio rerio)
HRH2:histamine [plasma membrane] (Danio rerio)
Hist [extracellular region]
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Amine ligand-binding receptors (Danio rerio)
Histamine receptors (Danio rerio)
HRH2 binds hist (Danio rerio)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Danio rerio)
Hist [extracellular region]
HRH3 binds Hist (Danio rerio)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
HRH4 binds Hist (Danio rerio)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Danio rerio)
Hist [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Organic cation/anion/zwitterion transport (Danio rerio)
Organic cation transport (Danio rerio)
OCT1 transports organic cations into hepatic cells (Danio rerio)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Danio rerio)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
HRH4:Hist [plasma membrane] (Drosophila melanogaster)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
HRH4:Hist [plasma membrane] (Drosophila melanogaster)
Hist [extracellular region]
GPCR ligand binding (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Amine ligand-binding receptors (Drosophila melanogaster)
Histamine receptors (Drosophila melanogaster)
HRH3 binds Hist (Drosophila melanogaster)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Drosophila melanogaster)
Hist [extracellular region]
HRH4 binds Hist (Drosophila melanogaster)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Drosophila melanogaster)
Hist [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic cation transport (Drosophila melanogaster)
OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
AOC1 deaminates Hist (Gallus gallus)
Hist [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
G alpha (q) signalling events (Gallus gallus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
Hist [extracellular region]
G alpha (s) signalling events (Gallus gallus)
Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
HRH2:histamine [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Gallus gallus)
HRH2:histamine [plasma membrane] (Gallus gallus)
Hist [extracellular region]
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Amine ligand-binding receptors (Gallus gallus)
Histamine receptors (Gallus gallus)
HRH1 binds hist (Gallus gallus)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
HRH2 binds hist (Gallus gallus)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Gallus gallus)
Hist [extracellular region]
HRH3 binds Hist (Gallus gallus)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
HRH4 binds Hist (Gallus gallus)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Gallus gallus)
Hist [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic cation transport (Gallus gallus)
OCT1 transports organic cations into hepatic cells (Gallus gallus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Gallus gallus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
AOC1 deaminates Hist (Homo sapiens)
Hist [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Hist [extracellular region]
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
Hist [extracellular region]
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
Hist [extracellular region]
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Histamine receptors (Homo sapiens)
HRH1 binds hist (Homo sapiens)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
HRH2 binds hist (Homo sapiens)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Homo sapiens)
Hist [extracellular region]
HRH3 binds Hist (Homo sapiens)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
HRH4 binds Hist (Homo sapiens)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Homo sapiens)
Hist [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
OCT1 transports organic cations into hepatic cells (Homo sapiens)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Homo sapiens)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
AOC1 deaminates Hist (Mus musculus)
Hist [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
G alpha (q) signalling events (Mus musculus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
HRH1:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
HRH1:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
HRH1:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
HRH1:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
HRH1:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
Hist [extracellular region]
G alpha (s) signalling events (Mus musculus)
Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
HRH2:histamine [plasma membrane] (Mus musculus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
HRH2:histamine [plasma membrane] (Mus musculus)
Hist [extracellular region]
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Amine ligand-binding receptors (Mus musculus)
Histamine receptors (Mus musculus)
HRH1 binds hist (Mus musculus)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
HRH2 binds hist (Mus musculus)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Mus musculus)
Hist [extracellular region]
HRH3 binds Hist (Mus musculus)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
HRH4 binds Hist (Mus musculus)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Mus musculus)
Hist [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Organic cation/anion/zwitterion transport (Mus musculus)
Organic cation transport (Mus musculus)
OCT1 transports organic cations into hepatic cells (Mus musculus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Mus musculus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
AOC1 deaminates Hist (Rattus norvegicus)
Hist [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
HRH4:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
HRH4:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
G alpha (q) signalling events (Rattus norvegicus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
HRH1:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
HRH1:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Amine ligand-binding receptors (Rattus norvegicus)
Histamine receptors (Rattus norvegicus)
HRH1 binds hist (Rattus norvegicus)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
HRH2 binds hist (Rattus norvegicus)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
HRH3 binds Hist (Rattus norvegicus)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
HRH4 binds Hist (Rattus norvegicus)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Rattus norvegicus)
Hist [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic cation transport (Rattus norvegicus)
OCT1 transports organic cations into hepatic cells (Rattus norvegicus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
AOC1 deaminates Hist (Sus scrofa)
Hist [extracellular region]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (q) signalling events (Sus scrofa)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
HRH1:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
HRH1:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
HRH1:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
HRH1:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
HRH1:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Sus scrofa)
Hist [extracellular region]
G alpha (s) signalling events (Sus scrofa)
Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Sus scrofa)
HRH2:histamine [plasma membrane] (Sus scrofa)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Sus scrofa)
HRH2:histamine [plasma membrane] (Sus scrofa)
Hist [extracellular region]
GPCR ligand binding (Sus scrofa)
Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
Amine ligand-binding receptors (Sus scrofa)
Histamine receptors (Sus scrofa)
HRH1 binds hist (Sus scrofa)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
HRH2 binds hist (Sus scrofa)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Sus scrofa)
Hist [extracellular region]
HRH3 binds Hist (Sus scrofa)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Sus scrofa)
Hist [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic cation transport (Sus scrofa)
OCT1 transports organic cations into hepatic cells (Sus scrofa)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Sus scrofa)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)
OCT2 substrates [extracellular region]
Hist [extracellular region]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
AOC1 deaminates Hist (Xenopus tropicalis)
Hist [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
G alpha (q) signalling events (Xenopus tropicalis)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Xenopus tropicalis)
HRH1:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Xenopus tropicalis)
HRH1:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Xenopus tropicalis)
HRH1:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Xenopus tropicalis)
Hist [extracellular region]
G alpha (s) signalling events (Xenopus tropicalis)
Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Xenopus tropicalis)
HRH2:histamine [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Xenopus tropicalis)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Xenopus tropicalis)
HRH2:histamine [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
GPCR ligand binding (Xenopus tropicalis)
Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
Amine ligand-binding receptors (Xenopus tropicalis)
Histamine receptors (Xenopus tropicalis)
HRH1 binds hist (Xenopus tropicalis)
Hist [extracellular region]
HRH1:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
HRH2 binds hist (Xenopus tropicalis)
Hist [extracellular region]
HRH2:histamine [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
HRH3 binds Hist (Xenopus tropicalis)
Hist [extracellular region]
HRH3:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
HRH4 binds Hist (Xenopus tropicalis)
Hist [extracellular region]
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
Hist [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Organic cation transport (Xenopus tropicalis)
OCT1 transports organic cations into hepatic cells (Xenopus tropicalis)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)
OCT1 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [extracellular region]
Hist [extracellular region]
OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [extracellular region]
Hist [extracellular region]
External Reference Information
External Reference
histaminium [ChEBI:58432]
Participates
as a component of
HRH3:Hist [plasma membrane] (Caenorhabditis elegans)
HRH3:Hist [plasma membrane] (Canis familiaris)
HRH3:Hist [plasma membrane] (Drosophila melanogaster)
HRH3:Hist [plasma membrane] (Mus musculus)
HRH3:Hist [plasma membrane] (Bos taurus)
HRH3:Hist [plasma membrane] (Gallus gallus)
HRH3:Hist [plasma membrane] (Sus scrofa)
HRH3:Hist [plasma membrane] (Rattus norvegicus)
HRH3:Hist [plasma membrane] (Xenopus tropicalis)
HRH3:Hist [plasma membrane] (Danio rerio)
HRH3:Hist [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Danio rerio)
HRH2:histamine [plasma membrane] (Gallus gallus)
HRH2:histamine [plasma membrane] (Bos taurus)
HRH2:histamine [plasma membrane] (Xenopus tropicalis)
HRH2:histamine [plasma membrane] (Mus musculus)
HRH2:histamine [plasma membrane] (Caenorhabditis elegans)
HRH2:histamine [plasma membrane] (Canis familiaris)
HRH2:histamine [plasma membrane] (Sus scrofa)
HRH4:Hist [plasma membrane] (Homo sapiens)
HRH4:Hist [plasma membrane] (Drosophila melanogaster)
HRH4:Hist [plasma membrane] (Xenopus tropicalis)
HRH4:Hist [plasma membrane] (Canis familiaris)
HRH4:Hist [plasma membrane] (Caenorhabditis elegans)
HRH4:Hist [plasma membrane] (Mus musculus)
HRH4:Hist [plasma membrane] (Rattus norvegicus)
HRH4:Hist [plasma membrane] (Bos taurus)
HRH4:Hist [plasma membrane] (Danio rerio)
HRH4:Hist [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Homo sapiens)
HRH1:Hist [plasma membrane] (Rattus norvegicus)
HRH1:Hist [plasma membrane] (Sus scrofa)
HRH1:Hist [plasma membrane] (Xenopus tropicalis)
HRH1:Hist [plasma membrane] (Gallus gallus)
HRH1:Hist [plasma membrane] (Mus musculus)
HRH1:Hist [plasma membrane] (Canis familiaris)
HRH2:histamine [plasma membrane] (Homo sapiens)
HRH2:histamine [plasma membrane] (Rattus norvegicus)
as an input of
HRH3 binds Hist (Caenorhabditis elegans)
HRH3 binds Hist (Drosophila melanogaster)
HRH3 binds Hist (Gallus gallus)
HRH3 binds Hist (Xenopus tropicalis)
HRH3 binds Hist (Danio rerio)
HRH3 binds Hist (Sus scrofa)
HRH3 binds Hist (Bos taurus)
HRH3 binds Hist (Canis familiaris)
HRH3 binds Hist (Rattus norvegicus)
HRH3 binds Hist (Mus musculus)
HRH3 binds Hist (Homo sapiens)
AOC1 deaminates Hist (Gallus gallus)
AOC1 deaminates Hist (Xenopus tropicalis)
AOC1 deaminates Hist (Danio rerio)
AOC1 deaminates Hist (Sus scrofa)
AOC1 deaminates Hist (Bos taurus)
AOC1 deaminates Hist (Canis familiaris)
AOC1 deaminates Hist (Rattus norvegicus)
AOC1 deaminates Hist (Mus musculus)
AOC1 deaminates Hist (Homo sapiens)
HRH2 binds hist (Caenorhabditis elegans)
HRH2 binds hist (Gallus gallus)
HRH2 binds hist (Xenopus tropicalis)
HRH2 binds hist (Danio rerio)
HRH2 binds hist (Sus scrofa)
HRH2 binds hist (Bos taurus)
HRH2 binds hist (Canis familiaris)
HRH2 binds hist (Rattus norvegicus)
HRH2 binds hist (Mus musculus)
HRH2 binds hist (Homo sapiens)
HRH4 binds Hist (Homo sapiens)
HRH4 binds Hist (Mus musculus)
HRH4 binds Hist (Rattus norvegicus)
HRH4 binds Hist (Canis familiaris)
HRH4 binds Hist (Bos taurus)
HRH4 binds Hist (Danio rerio)
HRH4 binds Hist (Xenopus tropicalis)
HRH4 binds Hist (Gallus gallus)
HRH4 binds Hist (Drosophila melanogaster)
HRH4 binds Hist (Caenorhabditis elegans)
HRH1 binds hist (Homo sapiens)
HRH1 binds hist (Mus musculus)
HRH1 binds hist (Rattus norvegicus)
HRH1 binds hist (Canis familiaris)
HRH1 binds hist (Sus scrofa)
HRH1 binds hist (Xenopus tropicalis)
HRH1 binds hist (Gallus gallus)
as a member of
OCT2 substrates [extracellular region]
OCT1 substrates [extracellular region]
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Sus scrofa)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Danio rerio)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Xenopus tropicalis)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
Other forms of this molecule
Hist [clathrin-sculpted monoamine transport vesicle lumen]
Hist [cytosol]
Cross References
COMPOUND
C00388
ZINC
000000388081
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