H3 and H4 receptors binds histamine

Stable Identifier
Reaction [binding]
Homo sapiens
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Histamine H3 receptor (Lovenberg TW et al, 1999) is predominantly expressed in the CNS and is involved in decreasing the release of neurotransmitters such as histamine, acetylcholine, norepinephrine and serotonin. There are currently at least six isoforms of the H3 receptor in humans of which isoforms 1,2 and 4 encode functional proteins (Wellendorph P et al, 2002).
Histamine H4 receptor (Nakamura T et al, 2000) is highly expressed in bone marrow and white blood cells. It is also found in other tissues such as colon, liver, lungs and thymus. The H4 receptor mediates mast cell chemotaxis. Both the H3 and H4 receptors mediate their actions by coupling with the G protein alpha-i subtype, thus decreasing intracellular cAMP.

Literature References
PubMed ID Title Journal Year
10347254 Cloning and functional expression of the human histamine H3 receptor

Lovenberg, TW, Roland, BL, Wilson, SJ, Jiang, X, Pyati, J, Huvar, A, Jackson, MR, Erlander, MG

Mol Pharmacol 1999
12069903 Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor

Wellendorph, P, Goodman, MW, Burstein, ES, Nash, NR, Brann, MR, Weiner, DM

Neuropharmacology 2002
11118334 Molecular cloning and characterization of a new human histamine receptor, HH4R

Nakamura, T, Itadani, H, Hidaka, Y, Ohta, M, Tanaka, K

Biochem Biophys Res Commun 2000
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