HRH4 binds Hist

Stable Identifier
R-HSA-390886
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Histamine H4 receptor (HRH4) (Nakamura et al. 2000) is highly expressed in bone marrow and white blood cells. It is also found in other tissues such as colon, liver, lungs and thymus. HRH4 mediates mast cell chemotaxis. Both the H3 and H4 receptors mediate their actions by coupling with the G protein alpha-i subtype, decreasing intracellular cAMP.

Literature References
PubMed ID Title Journal Year
11118334 Molecular cloning and characterization of a new human histamine receptor, HH4R

Nakamura, T, Itadani, H, Hidaka, Y, Ohta, M, Tanaka, K

Biochem Biophys Res Commun 2000
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