Reactome | HRH2 binds hist

HRH2 binds hist

Stable Identifier

R-HSA-390909

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Histamine receptors (Homo sapiens)
        
        HRH2 binds hist (Homo sapiens)

General

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Histamine H2 receptors (Gantz I et al, 1991) are primarily located on parietal cells (oxyntic cells) which are the stomach epithelium cells that secrete gastric acid in response to histamine. This action is modulated by coupling of the activated receptor with the G protein alpha-s subtype which can stimulate adenylate cyclase (Mitsuhashi M et al, 1989). Through a separate mechanism, the activated receptor can also couple with the G protein alpha-q/11 to stimulate phospholipase C (Mitsuhashi M et al, 1989). H2-receptor antagonists (H2RA) are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells.They are used in the treatment of dyspepsia.

Literature References

PubMed ID	Title	Journal	Year
1714721	Molecular cloning of the human histamine H2 receptor Gantz, I, Munzert, G, Tashiro, T, Schäffer, M, Wang, L, DelValle, J, Yamada, T	Biochem Biophys Res Commun	1991
2553705	Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells Mitsuhashi, M, Mitsuhashi, T, Payan, DG	J Biol Chem	1989