CEMIP hydrolyses HA

Stable Identifier
R-HSA-5693356
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The cell migration-inducing and hyaluronan-binding protein CEMIP (KIAA1199) is able to depolymerise high molecular weight hyaluronic acid (HA) polymers into intermediate-sized products. It randomly hydrolyses of 1-4 linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues of HA. CEMIP may play a key role in HA catabolism in the dermis of the skin and arthritic synovium (Yoshida et al. 2013).

Literature References
PubMed ID Title Journal Year
23509262 KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

Yoshida, H, Nagaoka, A, Kusaka-Kikushima, A, Tobiishi, M, Kawabata, K, Sayo, T, Sakai, S, Sugiyama, Y, Enomoto, H, Okada, Y, Inoue, S

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hyalurononglucosaminidase activity of CEMIP [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created