The cell migration-inducing and hyaluronan-binding protein CEMIP (KIAA1199) is able to depolymerise high molecular weight hyaluronic acid (HA) polymers into intermediate-sized products. It randomly hydrolyses of 1-4 linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues of HA. CEMIP may play a key role in HA catabolism in the dermis of the skin and arthritic synovium (Yoshida et al. 2013).
Inoue, S, Kusaka-Kikushima, A, Sayo, T, Sakai, S, Yoshida, H, Tobiishi, M, Sugiyama, Y, Okada, Y, Kawabata, K, Nagaoka, A, Enomoto, H
hyalurononglucosaminidase activity of CEMIP [extracellular region]
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