Reactome | HRH1 binds hist

HRH1 binds hist

Stable Identifier

R-HSA-390912

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Histamine receptors (Homo sapiens)
        
        HRH1 binds hist (Homo sapiens)

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The histamine H1 receptor (De Backer MD et al, 1993) is found on smooth muscle, endothelium and the CNS. Histamine released from neurons binds to the H1 receptor and causes systemic vasodilation and increased endothelial cell permeability. The effects are modulated by the activated receptor binding to the G protein alpha-q/11 subtype which can activate phospholipase C and the phosphatidylinositol (PIP2) signaling pathway (Tilly BC et al, 1990). The classical antihistamines (histamine H1 receptor antagonists) were developed in the early 1930s and were shown to reduce the effects of histamine on many tissues.

Literature References

PubMed ID	Title	Journal	Year
2155607	Histamine-H1-receptor-mediated phosphoinositide hydrolysis, Ca2+ signalling and membrane-potential oscillations in human HeLa carcinoma cells Tilly, BC, Tertoolen, LG, Lambrechts, AC, Remorie, R, de Laat, SW, Moolenaar, WH	Biochem J	1990
8280179	Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor De Backer, MD, Gommeren, W, Moereels, H, Nobels, G, Van Gompel, P, Leysen, JE, Luyten, WH	Biochem Biophys Res Commun	1993