H1 receptor binds histamine

Stable Identifier
R-HSA-390912
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The histamine H1 receptor (De Backer MD et al, 1993) is found on smooth muscle, endothelium and the CNS. Histamine released from neurons binds to the H1 receptor and causes systemic vasodilation and increased endothelial cell permeability. The effects are modulated by the activated receptor binding to the G protein alpha-q/11 subtype which can activate phospholipase C and the phosphatidylinositol (PIP2) signaling pathway (Tilly BC et al, 1990). The classical antihistamines (histamine H1 receptor antagonists) were developed in the early 1930s and were shown to reduce the effects of histamine on many tissues.

Literature References
PubMed ID Title Journal Year
8280179 Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor

De Backer, MD, Gommeren, W, Moereels, H, Nobels, G, Van Gompel, P, Leysen, JE, Luyten, WH

Biochem Biophys Res Commun 1993
2155607 Histamine-H1-receptor-mediated phosphoinositide hydrolysis, Ca2+ signalling and membrane-potential oscillations in human HeLa carcinoma cells

Tilly, BC, Tertoolen, LG, Lambrechts, AC, Remorie, R, de Laat, SW, Moolenaar, WH

Biochem J 1990
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