AOC1 deaminates Hist

Stable Identifier
R-HSA-5696131
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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AOC1 deaminates Hist
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Amiloride-sensitive, copper-containing amine oxidase (AOC1) can catalyse the oxidative deamination of diamines, particularly histamine (Hist) (McGrath et al. 2009). Histamine is involved in allergic and immune responses.
Literature References
PubMed ID Title Journal Year
19764817 Structure and inhibition of human diamine oxidase

Dooley, DM, Collyer, CA, Elmore, BO, Shepard, EM, Guss, JM, McGrath, AP, Hilmer, KM, Brown, DE

Biochemistry 2009
Participants
Input
Output
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as an event of
Catalyst Activity

histamine oxidase activity of AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane]

Physical Entity
AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane] (Homo sapiens)
Activity
histamine oxidase activity (GO:0052598)
Orthologous Events
AOC1 deaminates Hist (Bos taurus)
AOC1 deaminates Hist (Danio rerio)
AOC1 deaminates Hist (Gallus gallus)
AOC1 deaminates Hist (Mus musculus)
AOC1 deaminates Hist (Rattus norvegicus)
AOC1 deaminates Hist (Sus scrofa)
AOC1 deaminates Hist (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-27)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-27)
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