Amiloride-sensitive, copper-containing amine oxidase (AOC1) can catalyse the oxidative deamination of diamines, particularly histamine (Hist) (McGrath et al. 2009). Histamine is involved in allergic and immune responses.
Dooley, DM, Collyer, CA, Elmore, BO, Shepard, EM, Guss, JM, McGrath, AP, Hilmer, KM, Brown, DE
histamine oxidase activity of AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane]
© 2023 Reactome
