Reactome | HRH3 binds Hist

HRH3 binds Hist

Stable Identifier

R-HSA-9692880

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Histamine receptors (Homo sapiens)
        
        HRH3 binds Hist (Homo sapiens)

General

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Histamine H3 receptor (HRH3) (Lovenberg et al. 1999) is predominantly expressed in the CNS and is involved in decreasing the release of neurotransmitters such as histamine, acetylcholine, norepinephrine and serotonin. There are currently at least six isoforms of the H3 receptor in humans of which isoforms 1,2 and 4 encode functional proteins (Wellendorph et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12069903	Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor Wellendorph, P, Goodman, MW, Burstein, ES, Nash, NR, Brann, MR, Weiner, DM	Neuropharmacology	2002
10347254	Cloning and functional expression of the human histamine H3 receptor Lovenberg, TW, Roland, BL, Wilson, SJ, Jiang, X, Pyati, J, Huvar, A, Jackson, MR, Erlander, MG	Mol Pharmacol	1999