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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
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5HT [cytosol]
Stable Identifier
R-ALL-209914
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
5-Hydroxytryptamine, serotonin, 3-(2-Aminoethyl)-1H-indol-5-ol, Enteramine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Amine Oxidase reactions (Bos taurus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
5HT [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Serotonin and melatonin biosynthesis (Bos taurus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)
5HT [cytosol]
N-acetylation of serotonin (Bos taurus)
5HT [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Serotonin clearance from the synaptic cleft (Bos taurus)
Metabolism of serotonin (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
5HT [cytosol]
Neurotransmitter release cycle (Bos taurus)
Serotonin Neurotransmitter Release Cycle (Bos taurus)
loading of Serotonin in synaptic vesicles (Bos taurus)
5HT [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Na+/Cl- dependent neurotransmitter transporters (Bos taurus)
VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Bos taurus)
Organic cation transport (Bos taurus)
OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Bos taurus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Bos taurus)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Serotonin and melatonin biosynthesis (Caenorhabditis elegans)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)
5HT [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter clearance (Caenorhabditis elegans)
Serotonin clearance from the synaptic cleft (Caenorhabditis elegans)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
5HT [cytosol]
Neurotransmitter release cycle (Caenorhabditis elegans)
Serotonin Neurotransmitter Release Cycle (Caenorhabditis elegans)
loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)
5HT [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Na+/Cl- dependent neurotransmitter transporters (Caenorhabditis elegans)
VMAT1/2 can mediate the transport of biogenic amines (Caenorhabditis elegans)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic cation transport (Caenorhabditis elegans)
OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)
OCT2 substrates [cytosol]
5HT [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Amine Oxidase reactions (Canis familiaris)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
5HT [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of amine-derived hormones (Canis familiaris)
Serotonin and melatonin biosynthesis (Canis familiaris)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)
5HT [cytosol]
N-acetylation of serotonin (Canis familiaris)
5HT [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Serotonin clearance from the synaptic cleft (Canis familiaris)
Metabolism of serotonin (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
5HT [cytosol]
Neurotransmitter release cycle (Canis familiaris)
Serotonin Neurotransmitter Release Cycle (Canis familiaris)
loading of Serotonin in synaptic vesicles (Canis familiaris)
5HT [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Na+/Cl- dependent neurotransmitter transporters (Canis familiaris)
VMAT1/2 can mediate the transport of biogenic amines (Canis familiaris)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic cation transport (Canis familiaris)
OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Canis familiaris)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Canis familiaris)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Metabolism of amine-derived hormones (Danio rerio)
Serotonin and melatonin biosynthesis (Danio rerio)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)
5HT [cytosol]
N-acetylation of serotonin (Danio rerio)
5HT [cytosol]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter clearance (Danio rerio)
Serotonin clearance from the synaptic cleft (Danio rerio)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)
5HT [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Organic cation/anion/zwitterion transport (Danio rerio)
Organic cation transport (Danio rerio)
OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Danio rerio)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Danio rerio)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Amine Oxidase reactions (Dictyostelium discoideum)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
5HT [cytosol]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter clearance (Dictyostelium discoideum)
Serotonin clearance from the synaptic cleft (Dictyostelium discoideum)
Metabolism of serotonin (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
5HT [cytosol]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of vitamins, nucleosides, and related molecules (Dictyostelium discoideum)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Dictyostelium discoideum)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Serotonin and melatonin biosynthesis (Drosophila melanogaster)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)
5HT [cytosol]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter clearance (Drosophila melanogaster)
Serotonin clearance from the synaptic cleft (Drosophila melanogaster)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
5HT [cytosol]
Neurotransmitter release cycle (Drosophila melanogaster)
Serotonin Neurotransmitter Release Cycle (Drosophila melanogaster)
loading of Serotonin in synaptic vesicles (Drosophila melanogaster)
5HT [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Na+/Cl- dependent neurotransmitter transporters (Drosophila melanogaster)
VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic cation transport (Drosophila melanogaster)
OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Drosophila melanogaster)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Drosophila melanogaster)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
Amine Oxidase reactions (Gallus gallus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
5HT [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of amine-derived hormones (Gallus gallus)
Serotonin and melatonin biosynthesis (Gallus gallus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Gallus gallus)
5HT [cytosol]
N-acetylation of serotonin (Gallus gallus)
5HT [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter clearance (Gallus gallus)
Serotonin clearance from the synaptic cleft (Gallus gallus)
Metabolism of serotonin (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
5HT [cytosol]
Neurotransmitter release cycle (Gallus gallus)
Serotonin Neurotransmitter Release Cycle (Gallus gallus)
loading of Serotonin in synaptic vesicles (Gallus gallus)
5HT [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Na+/Cl- dependent neurotransmitter transporters (Gallus gallus)
VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic cation transport (Gallus gallus)
OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Gallus gallus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Gallus gallus)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective MAOA causes BRUNS (Homo sapiens)
Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)
5HT [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Amine Oxidase reactions (Homo sapiens)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
5HT [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Serotonin and melatonin biosynthesis (Homo sapiens)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Homo sapiens)
5HT [cytosol]
N-acetylation of serotonin (Homo sapiens)
5HT [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Serotonin clearance from the synaptic cleft (Homo sapiens)
Metabolism of serotonin (Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
5HT [cytosol]
Neurotransmitter release cycle (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
loading of Serotonin in synaptic vesicles (Homo sapiens)
5HT [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
Reuptake of serotonin from the synapse (Homo sapiens)
5HT [cytosol]
VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Homo sapiens)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Amine Oxidase reactions (Mus musculus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Mus musculus)
MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
5HT [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of amine-derived hormones (Mus musculus)
Serotonin and melatonin biosynthesis (Mus musculus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Mus musculus)
5HT [cytosol]
N-acetylation of serotonin (Mus musculus)
5HT [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter clearance (Mus musculus)
Serotonin clearance from the synaptic cleft (Mus musculus)
Metabolism of serotonin (Mus musculus)
MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
5HT [cytosol]
Neurotransmitter release cycle (Mus musculus)
Serotonin Neurotransmitter Release Cycle (Mus musculus)
loading of Serotonin in synaptic vesicles (Mus musculus)
5HT [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Na+/Cl- dependent neurotransmitter transporters (Mus musculus)
VMAT1/2 can mediate the transport of biogenic amines (Mus musculus)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Mus musculus)
Organic cation transport (Mus musculus)
OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Mus musculus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Mus musculus)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Neuronal System (Plasmodium falciparum)
Transmission across Chemical Synapses (Plasmodium falciparum)
Neurotransmitter clearance (Plasmodium falciparum)
Serotonin clearance from the synaptic cleft (Plasmodium falciparum)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)
5HT [cytosol]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of vitamins, nucleosides, and related molecules (Plasmodium falciparum)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Plasmodium falciparum)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Amine Oxidase reactions (Rattus norvegicus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Rattus norvegicus)
MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
5HT [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Metabolism of amine-derived hormones (Rattus norvegicus)
Serotonin and melatonin biosynthesis (Rattus norvegicus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)
5HT [cytosol]
N-acetylation of serotonin (Rattus norvegicus)
5HT [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter clearance (Rattus norvegicus)
Serotonin clearance from the synaptic cleft (Rattus norvegicus)
Metabolism of serotonin (Rattus norvegicus)
MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
5HT [cytosol]
Neurotransmitter release cycle (Rattus norvegicus)
Serotonin Neurotransmitter Release Cycle (Rattus norvegicus)
loading of Serotonin in synaptic vesicles (Rattus norvegicus)
5HT [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Na+/Cl- dependent neurotransmitter transporters (Rattus norvegicus)
VMAT1/2 can mediate the transport of biogenic amines (Rattus norvegicus)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic cation transport (Rattus norvegicus)
OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Rattus norvegicus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Rattus norvegicus)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Metabolism of amine-derived hormones (Saccharomyces cerevisiae)
Serotonin and melatonin biosynthesis (Saccharomyces cerevisiae)
N-acetylation of serotonin (Saccharomyces cerevisiae)
5HT [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Metabolism of amine-derived hormones (Schizosaccharomyces pombe)
Serotonin and melatonin biosynthesis (Schizosaccharomyces pombe)
N-acetylation of serotonin (Schizosaccharomyces pombe)
5HT [cytosol]
Neuronal System (Schizosaccharomyces pombe)
Transmission across Chemical Synapses (Schizosaccharomyces pombe)
Neurotransmitter release cycle (Schizosaccharomyces pombe)
Serotonin Neurotransmitter Release Cycle (Schizosaccharomyces pombe)
loading of Serotonin in synaptic vesicles (Schizosaccharomyces pombe)
5HT [cytosol]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of bile salts and organic acids, metal ions and amine compounds (Schizosaccharomyces pombe)
Na+/Cl- dependent neurotransmitter transporters (Schizosaccharomyces pombe)
VMAT1/2 can mediate the transport of biogenic amines (Schizosaccharomyces pombe)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
Amine Oxidase reactions (Sus scrofa)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Sus scrofa)
MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
5HT [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of amine-derived hormones (Sus scrofa)
Serotonin and melatonin biosynthesis (Sus scrofa)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)
5HT [cytosol]
N-acetylation of serotonin (Sus scrofa)
5HT [cytosol]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter clearance (Sus scrofa)
Serotonin clearance from the synaptic cleft (Sus scrofa)
Metabolism of serotonin (Sus scrofa)
MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
5HT [cytosol]
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
5HT [cytosol]
Neurotransmitter release cycle (Sus scrofa)
Serotonin Neurotransmitter Release Cycle (Sus scrofa)
loading of Serotonin in synaptic vesicles (Sus scrofa)
5HT [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Na+/Cl- dependent neurotransmitter transporters (Sus scrofa)
VMAT1/2 can mediate the transport of biogenic amines (Sus scrofa)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic cation transport (Sus scrofa)
OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)
OCT2 substrates [cytosol]
5HT [cytosol]
Transport of vitamins, nucleosides, and related molecules (Sus scrofa)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Sus scrofa)
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)
ligands of SLC29A4 [cytosol]
5HT [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Metabolism of amine-derived hormones (Xenopus tropicalis)
Serotonin and melatonin biosynthesis (Xenopus tropicalis)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Xenopus tropicalis)
5HT [cytosol]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter clearance (Xenopus tropicalis)
Serotonin clearance from the synaptic cleft (Xenopus tropicalis)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
5HT [cytosol]
Neurotransmitter release cycle (Xenopus tropicalis)
Serotonin Neurotransmitter Release Cycle (Xenopus tropicalis)
loading of Serotonin in synaptic vesicles (Xenopus tropicalis)
5HT [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Na+/Cl- dependent neurotransmitter transporters (Xenopus tropicalis)
VMAT1/2 can mediate the transport of biogenic amines (Xenopus tropicalis)
Biogenic amines transported by VMAT1/2 [cytosol]
5HT [cytosol]
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Organic cation transport (Xenopus tropicalis)
OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [cytosol]
5HT [cytosol]
OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)
OCT2 substrates [cytosol]
5HT [cytosol]
External Reference Information
External Reference
serotonin(1+) [ChEBI:350546]
Participates
as an input of
Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
loading of Serotonin in synaptic vesicles (Homo sapiens)
loading of Serotonin in synaptic vesicles (Mus musculus)
loading of Serotonin in synaptic vesicles (Rattus norvegicus)
loading of Serotonin in synaptic vesicles (Canis familiaris)
loading of Serotonin in synaptic vesicles (Bos taurus)
loading of Serotonin in synaptic vesicles (Sus scrofa)
loading of Serotonin in synaptic vesicles (Xenopus tropicalis)
loading of Serotonin in synaptic vesicles (Gallus gallus)
loading of Serotonin in synaptic vesicles (Drosophila melanogaster)
loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)
loading of Serotonin in synaptic vesicles (Schizosaccharomyces pombe)
N-acetylation of serotonin (Bos taurus)
N-acetylation of serotonin (Homo sapiens)
N-acetylation of serotonin (Mus musculus)
N-acetylation of serotonin (Rattus norvegicus)
N-acetylation of serotonin (Canis familiaris)
N-acetylation of serotonin (Sus scrofa)
N-acetylation of serotonin (Danio rerio)
N-acetylation of serotonin (Gallus gallus)
N-acetylation of serotonin (Schizosaccharomyces pombe)
N-acetylation of serotonin (Saccharomyces cerevisiae)
MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
as an output of
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Homo sapiens)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Mus musculus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Xenopus tropicalis)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Gallus gallus)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)
Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)
Reuptake of serotonin from the synapse (Homo sapiens)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
as a member of
Biogenic amines transported by VMAT1/2 [cytosol]
OCT2 substrates [cytosol]
ligands of SLC29A4 [cytosol]
Other forms of this molecule
5HT [platelet dense granule lumen]
5HT [clathrin-sculpted monoamine transport vesicle lumen]
5HT [extracellular region]
Cross References
COMPOUND
C00780
ZINC
000000057058
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