SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-444008
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
SERT mediates serotonin uptake
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Serotonin (5HT) is a monoamine neurotransmitter. It's clearance (and therefore termination) from the synaptic cleft is mediated by the sodium- and chloride-dependent serotonin transporter SERT (SLC6A4, aka 5HTT). SERT is encoded by the human gene SLC6A4 and is expressed in the CNS, PNS and platelets (Ramamoorthy et al. 1993, Brenner et al. 2007, Canli & Lesch 2007).

Literature References
PubMed ID Title Journal Year
7681602 Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

Chang, AS, Han, H, Moore, KR, Bauman, AL, Blakely, RD, Ganapathy, V, Yang-Feng, T, Ramamoorthy, S

Proc Natl Acad Sci U S A 1993
17726476 Long story short: the serotonin transporter in emotion regulation and social cognition

Lesch, KP, Canli, T

Nat Neurosci 2007
17506858 Plasma serotonin levels and the platelet serotonin transporter

Ahmed, BA, Brenner, B, Unal, R, Harney, JT, Jeffus, BC, Mehta, JL, Kilic, F

J. Neurochem. 2007
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Event Information
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Catalyst Activity

serotonin:sodium symporter activity of SLC6A4 [plasma membrane]

Orthologous Events
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Rhea
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