SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-444008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
Synonyms
SERT mediates serotonin uptake
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Serotonin (5HT) is a monoamine neurotransmitter. It's clearance (and therefore termination) from the synaptic cleft is mediated by the sodium- and chloride-dependent serotonin transporter SERT (SLC6A4, aka 5HTT). SERT is encoded by the human gene SLC6A4 and is expressed in the CNS, PNS and platelets (Ramamoorthy et al. 1993, Brenner et al. 2007, Canli & Lesch 2007).
Literature References
PubMed ID Title Journal Year
7681602 Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

Ramamoorthy, S, Bauman, AL, Moore, KR, Han, H, Yang-Feng, T, Chang, AS, Ganapathy, V, Blakely, RD

Proc Natl Acad Sci U S A 1993
17726476 Long story short: the serotonin transporter in emotion regulation and social cognition

Canli, T, Lesch, KP

Nat Neurosci 2007
17506858 Plasma serotonin levels and the platelet serotonin transporter

Brenner, B, Harney, JT, Ahmed, BA, Jeffus, BC, Unal, R, Mehta, JL, Kilic, F

J. Neurochem. 2007
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
serotonin uptake (0051610)
Catalyst Activity

serotonin:sodium:chloride symporter activity of SLC6A4 [plasma membrane]

Physical Entity
SLC6A4 [plasma membrane] (Homo sapiens)
Activity
serotonin:sodium:chloride symporter activity (GO:0005335)
Orthologous Events
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2009-10-20)
Reviewed
Huertas, J  (2016-03-08)
Created
Jassal, B  (2009-10-20)
Cite Us!