Serotonin (5HT) is a monoamine neurotransmitter. It's clearance (and therefore termination) from the synaptic cleft is mediated by the sodium- and chloride-dependent serotonin transporter SERT (SLC6A4, aka 5HTT). SERT is encoded by the human gene SLC6A4 and is expressed in the CNS, PNS and platelets (Ramamoorthy et al. 1993, Brenner et al. 2007, Canli & Lesch 2007).
Chang, AS, Han, H, Moore, KR, Bauman, AL, Blakely, RD, Ganapathy, V, Yang-Feng, T, Ramamoorthy, S
Lesch, KP, Canli, T
Ahmed, BA, Brenner, B, Unal, R, Harney, JT, Jeffus, BC, Mehta, JL, Kilic, F
serotonin:sodium symporter activity of SLC6A4 [plasma membrane]
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