Reactome | Decarboxylation of 5-hydroxytryptophan forms serotonin

Decarboxylation of 5-hydroxytryptophan forms serotonin

Stable Identifier

R-HSA-209859

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Decarboxylation of 5-hydroxytryptophan forms serotonin

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Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both dopa and 5-hydroxytryptophan to dopamine and serotonin, respectively. AADC functions as a homodimer, utilizing pyridoxal phosphate as a cofactor.

Literature References

PubMed ID	Title	Journal	Year
2590185	Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase Ichinose, H, Kurosawa, Y, Titani, K, Fujita, K, Nagatsu, T	Biochem Biophys Res Commun	1989
1540578	Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis Sumi-Ichinose, C, Ichinose, H, Takahashi, E, Hori, T, Nagatsu, T	Biochemistry	1992