Reactome | Decarboxylation of 5-hydroxytryptophan forms serotonin

Decarboxylation of 5-hydroxytryptophan forms serotonin

Stable Identifier

R-HSA-209859

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Decarboxylation of 5-hydroxytryptophan forms serotonin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both dopa and 5-hydroxytryptophan to dopamine and serotonin, respectively. AADC functions as a homodimer, utilizing pyridoxal phosphate as a cofactor.

Literature References

PubMed ID	Title	Journal	Year
1540578	Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis Hori, T, Ichinose, H, Takahashi, E, Sumi-Ichinose, C, Nagatsu, T	Biochemistry	1992
2590185	Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase Titani, K, Ichinose, H, Fujita, K, Nagatsu, T, Kurosawa, Y	Biochem Biophys Res Commun	1989