Reactome | MAOA:FAD oxidatively deaminates of 5HT

MAOA:FAD oxidatively deaminates of 5HT

Stable Identifier

R-HSA-141186

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

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Amine oxidase (flavin-containing) A (MAOA) catalyses the oxidative deamination of biogenic and dietary amines, the regulation of which is critical for mental state homeostasis. MAOA, located on the mitochondrial outer membrane and requiring FAD as cofactor (Weyler 1989), preferentially oxidises biogenic amines such as 5-hydroxytryptamine (5HT), dopamine, noradrenaline and adrenaline (latter three not shown here). 5HT is deaminated to 5-hydroxyindolacetaldehyde (5HIALD).

Literature References

PubMed ID	Title	Journal	Year
2764901	Monoamine oxidase A from human placenta and monoamine oxidase B from bovine liver both have one FAD per subunit Weyler, W	Biochem. J.	1989
6408492	The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions O'Carroll, AM, Fowler, CJ, Phillips, JP, Tobbia, I, Tipton, KF	Naunyn Schmiedebergs Arch Pharmacol	1983