Reuptake of serotonin from the synapse

Stable Identifier
R-HSA-380620
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Reuptake of serotonin from the synapse
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The human gene SLC6A4 encodes the sodium-dependent serotonin transporter 5HTT which mediates the re-uptake of serotonin from the synaptic cleft thus terminating the action of serotonin (Canli T and Lesch KP, 2007). The serotonin taken up in the cytosol from the synaptic cleft may be recycled into synaptic vesicles or metabolized.
Literature References
PubMed ID Title Journal Year
17726476 Long story short: the serotonin transporter in emotion regulation and social cognition

Canli, T, Lesch, KP

Nat Neurosci 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monoamine transmembrane transporter activity of SLC6A4 [plasma membrane]

Physical Entity
SLC6A4 [plasma membrane] (Homo sapiens)
Activity
monoamine transmembrane transporter activity (GO:0008504)
Orthologous Events
Reuptake of serotonin from the synapse (Bos taurus)
Reuptake of serotonin from the synapse (Caenorhabditis elegans)
Reuptake of serotonin from the synapse (Canis familiaris)
Reuptake of serotonin from the synapse (Danio rerio)
Reuptake of serotonin from the synapse (Drosophila melanogaster)
Reuptake of serotonin from the synapse (Gallus gallus)
Reuptake of serotonin from the synapse (Mus musculus)
Reuptake of serotonin from the synapse (Plasmodium falciparum)
Reuptake of serotonin from the synapse (Rattus norvegicus)
Reuptake of serotonin from the synapse (Sus scrofa)
Reuptake of serotonin from the synapse (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-11-13)
Cite Us!