Reuptake of serotonin from the synapse

Stable Identifier
R-HSA-380620
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC6A4 encodes the sodium-dependent serotonin transporter 5HTT which mediates the re-uptake of serotonin from the synaptic cleft thus terminating the action of serotonin (Canli T and Lesch KP, 2007). The serotonin taken up in the cytosol from the synaptic cleft may be recycled into synaptic vesicles or metabolized.

Literature References
PubMed ID Title Journal Year
17726476 Long story short: the serotonin transporter in emotion regulation and social cognition

Canli, T, Lesch, KP

Nat Neurosci 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monoamine transmembrane transporter activity of Sodium dependent Serotonin transporter [plasma membrane]
Physical Entity
Activity
Authored
Reviewed
Created
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