Reactome | Ub [nucleoplasm]

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Ub [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-69598] Ubiquitination of phosphorylated CDC25A - Xenopus tropicalis [Reaction:R-XTR-69598] Ubiquitination of phosphorylated CDC25A - Xenopus tropicalis [Reaction:R-XTR-69598] Ubiquitination of phosphorylated CDC25A - Xenopus tropicalis [Reaction:R-XTR-6804942] MDM2 homodimers auto-ubiquitinate - Xenopus tropicalis [Reaction:R-XTR-6804942] MDM2 homodimers auto-ubiquitinate - Xenopus tropicalis [Reaction:R-XTR-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Xenopus tropicalis [Reaction:R-XTR-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Xenopus tropicalis [BlackBoxEvent:R-XTR-5655193] KIAA0101 double monoubiquitination - Xenopus tropicalis [BlackBoxEvent:R-XTR-5655193] KIAA0101 double monoubiquitination - Xenopus tropicalis [Reaction:R-XTR-5655170] RCHY1 monoubiquitinates POLH - Xenopus tropicalis [Reaction:R-XTR-5655170] RCHY1 monoubiquitinates POLH - Xenopus tropicalis [Reaction:R-XTR-5655170] RCHY1 monoubiquitinates POLH - Xenopus tropicalis [Reaction:R-XTR-5655170] RCHY1 monoubiquitinates POLH - Xenopus tropicalis [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 - Xenopus tropicalis [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 - Xenopus tropicalis [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 - Xenopus tropicalis [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 - Xenopus tropicalis [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 - Xenopus tropicalis [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 - Xenopus tropicalis [Reaction:R-XTR-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Xenopus tropicalis [Reaction:R-XTR-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Xenopus tropicalis [Reaction:R-XTR-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Xenopus tropicalis [Reaction:R-XTR-174057] Multiubiquitination of APC/C-associated Cdh1 - Xenopus tropicalis [Reaction:R-XTR-174057] Multiubiquitination of APC/C-associated Cdh1 - Xenopus tropicalis [Reaction:R-XTR-174057] Multiubiquitination of APC/C-associated Cdh1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Xenopus tropicalis [Reaction:R-XTR-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Xenopus tropicalis [Reaction:R-XTR-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Xenopus tropicalis [Reaction:R-XTR-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 - Xenopus tropicalis [Reaction:R-XTR-6798373] MDM2 ubiquitinates DYRK2 - Xenopus tropicalis [Reaction:R-XTR-6782943] UV-DDB ubiquitinates XPC - Xenopus tropicalis [Reaction:R-XTR-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952419] SMURFs ubiquitinate RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952419] SMURFs ubiquitinate RUNX3 - Xenopus tropicalis [Reaction:R-XTR-8952419] SMURFs ubiquitinate RUNX3 - Xenopus tropicalis [Reaction:R-XTR-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Xenopus tropicalis [Reaction:R-XTR-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Xenopus tropicalis [Reaction:R-XTR-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Xenopus tropicalis [Reaction:R-XTR-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Xenopus tropicalis [Reaction:R-XTR-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10651555
displayName	Ub [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-XTR-939844] rps27a [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-XTR-939847] ubc [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-XTR-939871] uba52 [nucleoplasm] - Xenopus tropicalis
inDisease	false
inferredFrom	[DefinedSet:R-HSA-68524] Ub [nucleoplasm] - Homo sapiens
maxDepth	2
name	Ub Ubiquitin UBIQ_HUMAN
producedByEvent	[BlackBoxEvent:R-XTR-188191] APC/C:Cdh1-mediated degradation of Skp2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-188191] APC/C:Cdh1-mediated degradation of Skp2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-188191] APC/C:Cdh1-mediated degradation of Skp2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Xenopus tropicalis [BlackBoxEvent:R-XTR-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Xenopus tropicalis [BlackBoxEvent:R-XTR-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Xenopus tropicalis [BlackBoxEvent:R-XTR-68825] Ubiquitinated geminin is degraded by the proteasome - Xenopus tropicalis [BlackBoxEvent:R-XTR-68825] Ubiquitinated geminin is degraded by the proteasome - Xenopus tropicalis [BlackBoxEvent:R-XTR-68825] Ubiquitinated geminin is degraded by the proteasome - Xenopus tropicalis [BlackBoxEvent:R-XTR-8939801] 26S proteasome degrades PolyUb-RUNX2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-8939801] 26S proteasome degrades PolyUb-RUNX2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-8939801] 26S proteasome degrades PolyUb-RUNX2 - Xenopus tropicalis [Reaction:R-XTR-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Xenopus tropicalis [Reaction:R-XTR-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Xenopus tropicalis [Reaction:R-XTR-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Xenopus tropicalis [Reaction:R-XTR-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Xenopus tropicalis [Reaction:R-XTR-3215295] USP7 deubiquitinates MDM2 - Xenopus tropicalis [Reaction:R-XTR-3215295] USP7 deubiquitinates MDM2 - Xenopus tropicalis [Reaction:R-XTR-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Xenopus tropicalis [Reaction:R-XTR-5690157] USP16,USP21 deubiquitinate Histone H2A - Xenopus tropicalis [Reaction:R-XTR-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B - Xenopus tropicalis [Reaction:R-XTR-5696960] USP49 deubiquitinates H2B - Xenopus tropicalis [Reaction:R-XTR-5691381] MYSM1 deubiquitinates Histone H2A - Xenopus tropicalis [Reaction:R-XTR-5690790] Histone H2A is dubiquitinated by the PR-DUB complex - Xenopus tropicalis [BlackBoxEvent:R-XTR-174058] Degradation of multiubiquitinated Cdh1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-174058] Degradation of multiubiquitinated Cdh1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-174058] Degradation of multiubiquitinated Cdh1 - Xenopus tropicalis [Reaction:R-XTR-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Xenopus tropicalis [Reaction:R-XTR-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Xenopus tropicalis [BlackBoxEvent:R-XTR-5635854] GLI2,3 are degraded by the proteasome - Xenopus tropicalis [BlackBoxEvent:R-XTR-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Xenopus tropicalis
schemaClass	DefinedSet
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-68524

Referrals

(hasComponent)	[Complex:R-XTR-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] [Complex:R-XTR-8852095] Ub-Cys632-UBA1 [nucleoplasm] [Complex:R-XTR-8942129] Ub:UBE2A,B [nucleoplasm] [Complex:R-XTR-5655177] MonoUb:K15,K24-KIAA0101 [nucleoplasm] [Complex:R-XTR-5651984] MonoUb:K164-PCNA [nucleoplasm] [Complex:R-XTR-2186733] Ub-SKI/Ub-SKIL [nucleoplasm] [Complex:R-XTR-2186778] Ub-SMAD7 [nucleoplasm] [Complex:R-XTR-187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] [Complex:R-XTR-174068] multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] [Complex:R-XTR-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] [Complex:R-XTR-1234123] UBE2D1,2,3:Ubiquitin [nucleoplasm] [Complex:R-XTR-1234100] ub-hydroxyPro-HIF-alpha [nucleoplasm] [Complex:R-XTR-3788734] Ub-EHMT1 [nucleoplasm] [Complex:R-XTR-3788727] Ub-EHMT2 [nucleoplasm] [Complex:R-XTR-6782951] Ub:XPC [nucleoplasm] [Complex:R-XTR-6790462] Ub,SUMO:XPC [nucleoplasm] [Complex:R-XTR-6781851] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] [Complex:R-XTR-6781849] Ub:ERCC6 [nucleoplasm] [Complex:R-XTR-420750] MonoUb:K523,p-4S-FANCI [nucleoplasm] [Complex:R-XTR-420751] MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] [Complex:R-XTR-5655156] MonoUb:K682,K686,K694,K709-POLH [nucleoplasm]
(input)	[Reaction:R-XTR-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus [Reaction:R-XTR-8852128] UBA1 adenylates ubiquitin in the nucleoplasm [BlackBoxEvent:R-XTR-5655193] KIAA0101 double monoubiquitination [Reaction:R-XTR-5655170] RCHY1 monoubiquitinates POLH [Reaction:R-XTR-2179276] SMURF2 monoubiquitinates SMAD3 [Reaction:R-XTR-9686969] APC/C:Cdh1 polyubiquitinates SKP2 [Reaction:R-XTR-174057] Multiubiquitination of APC/C-associated Cdh1 [Reaction:R-XTR-69598] Ubiquitination of phosphorylated CDC25A [BlackBoxEvent:R-XTR-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 [Reaction:R-XTR-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 [Reaction:R-XTR-6804942] MDM2 homodimers auto-ubiquitinate [Reaction:R-XTR-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 [Reaction:R-XTR-6798373] MDM2 ubiquitinates DYRK2 [Reaction:R-XTR-6782943] UV-DDB ubiquitinates XPC [Reaction:R-XTR-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II [Reaction:R-XTR-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 [Reaction:R-XTR-8952419] SMURFs ubiquitinate RUNX3 [Reaction:R-XTR-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1
(output)	[Reaction:R-XTR-5690157] USP16,USP21 deubiquitinate Histone H2A [Reaction:R-XTR-5690080] USP3,SAGA deubiquitinate Histone H2A,H2B [Reaction:R-XTR-5696960] USP49 deubiquitinates H2B [Reaction:R-XTR-5691381] MYSM1 deubiquitinates Histone H2A [Reaction:R-XTR-5690790] Histone H2A is dubiquitinated by the PR-DUB complex [BlackBoxEvent:R-XTR-174058] Degradation of multiubiquitinated Cdh1 [BlackBoxEvent:R-XTR-188191] APC/C:Cdh1-mediated degradation of Skp2 [BlackBoxEvent:R-XTR-69600] Proteolytic degradation of ubiquitinated-Cdc25A [BlackBoxEvent:R-XTR-68825] Ubiquitinated geminin is degraded by the proteasome [Reaction:R-XTR-6807118] USP7 deubiquitinates monoubiquitinated PTEN [BlackBoxEvent:R-XTR-8939801] 26S proteasome degrades PolyUb-RUNX2 [Reaction:R-XTR-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 [Reaction:R-XTR-3215295] USP7 deubiquitinates MDM2 [Reaction:R-XTR-6782069] UVSSA:USP7 deubiquitinates ERCC6 [BlackBoxEvent:R-XTR-5635854] GLI2,3 are degraded by the proteasome [BlackBoxEvent:R-XTR-9762096] Ub,pS335,S338,T NFE2L2 is degraded
(inferredTo)	[DefinedSet:R-HSA-68524] Ub [nucleoplasm]

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