Reactome | USP7 deubiquitinates TP53 and counteracts MDM2

Schema > Reaction > Entries

USP7 deubiquitinates TP53 and counteracts MDM2 Show undefined attributes

catalystActivity	[CatalystActivity:10692644] cysteine-type deubiquitinase activity of USP7 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10692646
displayName	USP7 deubiquitinates TP53 and counteracts MDM2
eventOf	[Pathway:R-XTR-6804757] Regulation of TP53 Degradation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-XTR-3209186] PolyUb-TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	USP7 deubiquitinates TP53 and counteracts MDM2
output	[Complex:R-XTR-3209194] TP53 Tetramer [nucleoplasm] 4 × [DefinedSet:R-XTR-68524] Ub [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3215310
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2

Cite Us!