Reactome | Ubiquitinated geminin is degraded by the proteasome

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Ubiquitinated geminin is degraded by the proteasome Show undefined attributes

catalystActivity	[CatalystActivity:10651773] endopeptidase activity of 26S proteasome [nucleoplasm]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10651775
displayName	Ubiquitinated geminin is degraded by the proteasome
eventOf	[Pathway:R-XTR-68867] Assembly of the pre-replicative complex - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-68825] Ubiquitinated geminin is degraded by the proteasome - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-68585] gmnn [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitinated geminin is degraded by the proteasome
output	3 × [DefinedSet:R-XTR-68524] Ub [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-XTR-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-68825
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-68867] Assembly of the pre-replicative complex
(inferredTo)	[BlackBoxEvent:R-HSA-68825] Ubiquitinated geminin is degraded by the proteasome

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