Reactome | UBA1 adenylates ubiquitin in the nucleoplasm

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UBA1 adenylates ubiquitin in the nucleoplasm Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10712757
displayName	UBA1 adenylates ubiquitin in the nucleoplasm
eventOf	[Pathway:R-XTR-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-8852136] UBA1 conjugates ubiquitin to UBA1 in the nucleus - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-XTR-68524] Ub [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-8852116] uba1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	UBA1 adenylates ubiquitin in the nucleoplasm
output	[SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [Complex:R-XTR-8852055] UBA1:ubiquitin adenylate [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8852128
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes
(precedingEvent)	[Reaction:R-XTR-8852136] UBA1 conjugates ubiquitin to UBA1 in the nucleus
(inferredTo)	[Reaction:R-HSA-8852128] UBA1 adenylates ubiquitin in the nucleoplasm

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