Reactome | Oxidative Stress Induced Senescence

Schema > Pathway > Entries

Oxidative Stress Induced Senescence Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556479
displayName	Oxidative Stress Induced Senescence
eventOf	[Pathway:R-SSC-2559583] Cellular Senescence - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Sus scrofa [Reaction:R-SSC-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Sus scrofa [Reaction:R-SSC-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Sus scrofa [Reaction:R-SSC-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Sus scrofa [Reaction:R-SSC-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Sus scrofa [Reaction:R-SSC-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Sus scrofa [Reaction:R-SSC-450348] Activated human JNKs migrate to nucleoplasm - Sus scrofa [Reaction:R-SSC-168136] Activated JNKs phosphorylate c-JUN - Sus scrofa [Reaction:R-SSC-450325] c-FOS activation by phospho ERK1/2 - Sus scrofa [Reaction:R-SSC-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Sus scrofa [Reaction:R-SSC-3240295] PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter - Sus scrofa [Reaction:R-SSC-3229089] PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter - Sus scrofa [Reaction:R-SSC-3229102] p-MAPKAPK3 phosphorylates BMI1 - Sus scrofa [Reaction:R-SSC-8979071] KDM6B binds iron - Sus scrofa [Reaction:R-SSC-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Sus scrofa [Reaction:R-SSC-182594] Association of INK4 family proteins with CDK4/6 - Sus scrofa [Reaction:R-SSC-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Sus scrofa [Reaction:R-SSC-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Sus scrofa [Reaction:R-SSC-3239014] MAPKAPK5 phosphorylates TP53 - Sus scrofa
inferredFrom	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Oxidative Stress Induced Senescence
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2559580
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-SSC-453279] Mitotic G1 phase and G1/S transition [Pathway:R-SSC-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-SSC-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-SSC-6804756] Regulation of TP53 Activity through Phosphorylation [Pathway:R-SSC-9833482] PKR-mediated signaling [Pathway:R-SSC-2559585] Oncogene Induced Senescence
(inferredTo)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence

© 2026 Reactome

Cite Us!