Reactome | Phosphorylation of human JNKs by activated MKK4/MKK7

Schema > Reaction > Entries

Phosphorylation of human JNKs by activated MKK4/MKK7 Show undefined attributes

catalystActivity	[CatalystActivity:10459423] JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459425
displayName	Phosphorylation of human JNKs by activated MKK4/MKK7
eventOf	[Pathway:R-SSC-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Sus scrofa [Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence - Sus scrofa [Pathway:R-SSC-2871796] FCERI mediated MAPK activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-450348] Activated human JNKs migrate to nucleoplasm - Sus scrofa
inferredFrom	[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-SSC-450289] MAPK8,9,10 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of human JNKs by activated MKK4/MKK7
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-SSC-450226] p-MAPK8,9,10 [cytosol]
precedingEvent	[Reaction:R-SSC-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-168162
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence [Pathway:R-SSC-2871796] FCERI mediated MAPK activation [Pathway:R-SSC-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
(precedingEvent)	[Reaction:R-SSC-450348] Activated human JNKs migrate to nucleoplasm
(inferredTo)	[Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7

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