Reactome | c-FOS activation by phospho ERK1/2

Schema > Reaction > Entries

c-FOS activation by phospho ERK1/2 Show undefined attributes

catalystActivity	[CatalystActivity:10464852] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10480551
displayName	c-FOS activation by phospho ERK1/2
eventOf	[Pathway:R-SSC-450341] Activation of the AP-1 family of transcription factors - Sus scrofa [Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence - Sus scrofa [Pathway:R-SSC-2871796] FCERI mediated MAPK activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Sus scrofa
inferredFrom	[Reaction:R-HSA-450325] c-FOS activation by phospho ERK1/2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-450216] FOS [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	c-FOS activation by phospho ERK1/2
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-450283] phospho-FOS [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-SSC-5674387] Phosphorylated MAPKs translocate into the nucleus - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-450325
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence [Pathway:R-SSC-2871796] FCERI mediated MAPK activation [Pathway:R-SSC-450341] Activation of the AP-1 family of transcription factors
(precedingEvent)	[Reaction:R-SSC-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
(inferredTo)	[Reaction:R-HSA-450325] c-FOS activation by phospho ERK1/2