Reactome | PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter

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PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter Show undefined attributes

catalystActivity	[CatalystActivity:10506919] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10506921
displayName	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
eventOf	[Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Sus scrofa
inferredFrom	[Reaction:R-HSA-3240295] PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter - Homo sapiens
input	6 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-SSC-3222592] CDKN2A Gene:Nucleosome [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
output	6 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-SSC-3222570] CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-3240295
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-SSC-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter
(inferredTo)	[Reaction:R-HSA-3240295] PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter

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