Reactome | PKR-mediated signaling

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PKR-mediated signaling Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558999
displayName	PKR-mediated signaling
eventOf	[Pathway:R-SSC-1169410] Antimicrobial mechanism of IFN-stimulated genes - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2454459] PKR/eIFalpha signaling
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-9833777] PKR binds activating host RNA - Sus scrofa [BlackBoxEvent:R-SSC-9833973] ISGylation of PKR - Sus scrofa [Reaction:R-SSC-9834821] p-PRKRA dimer binds PKR - Sus scrofa [Reaction:R-SSC-9834807] ILF3 binds PKR - Sus scrofa [Reaction:R-SSC-9835121] Heparin binds PKR - Sus scrofa [Reaction:R-SSC-9835189] NCK1 binds PKR - Sus scrofa [Reaction:R-SSC-9835328] NPM binds PKR - Sus scrofa [Reaction:R-SSC-9835358] p-TARBP2 binds PKR - Sus scrofa [Reaction:R-SSC-9835385] DUS2 binds PKR - Sus scrofa [Reaction:R-SSC-9835411] FA core complex:HSP70s binds PKR - Sus scrofa [Reaction:R-SSC-9835443] STAT1,STAT3 binds PKR - Sus scrofa [Reaction:R-SSC-9835454] DNAJC3 binds PKR - Sus scrofa [Reaction:R-SSC-9835944] ADAR1 binds PKR - Sus scrofa [Reaction:R-SSC-9836606] SPHK1 binds PKR - Sus scrofa [Reaction:R-SSC-9836702] PKR inhibitors bind PKR - Sus scrofa [BlackBoxEvent:R-SSC-9836159] p-PKR dimer phosphorylates DHX9 - Sus scrofa [Reaction:R-SSC-9836184] p-PKR dimer phosphorylates CDK1 - Sus scrofa [Reaction:R-SSC-9836322] p-PKR dimer phosphorylates MKK6 - Sus scrofa [BlackBoxEvent:R-SSC-9833635] p-PKR dimer localizes to the nucleus - Sus scrofa [Reaction:R-SSC-9836362] p-PKR dimer phosphorylates TP53 tetramer - Sus scrofa [Reaction:R-SSC-9836383] p-PKR dimer phosphorylates ILF3:ILF2 - Sus scrofa [Reaction:R-SSC-9836404] p-PKR dimer phosphorylates MAPT - Sus scrofa [Reaction:R-SSC-9836435] p-PKR dimer phosphorylates SNCA - Sus scrofa [Reaction:R-SSC-9836500] IKK complex is activated by PKR - Sus scrofa [Reaction:R-SSC-9836515] p-PKR dimer phosphorylates PTPN2 - Sus scrofa [Reaction:R-SSC-9836617] p-PKR dimer phosphorylates SPHK1 - Sus scrofa [BlackBoxEvent:R-SSC-9836621] p-S225-SPHK1 localizes to cytosol - Sus scrofa [Reaction:R-SSC-9836664] p-PKR dimer phosphorylates PPP2R5A - Sus scrofa
inferredFrom	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PKR-mediated signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9833482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1169410] Antimicrobial mechanism of IFN-stimulated genes
(hasEncapsulatedEvent)	[Pathway:R-SSC-4755510] SUMOylation of immune response proteins [Pathway:R-SSC-1169408] ISG15 antiviral mechanism [Pathway:R-SSC-194138] Signaling by VEGF [Pathway:R-SSC-909733] Interferon alpha/beta signaling
(inferredTo)	[Pathway:R-HSA-9833482] PKR-mediated signaling

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