Reactome | Senescence-Associated Secretory Phenotype (SASP)

Schema > Pathway > Entries

Senescence-Associated Secretory Phenotype (SASP) Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556663
displayName	Senescence-Associated Secretory Phenotype (SASP)
eventOf	[Pathway:R-SSC-2559583] Cellular Senescence - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 - Sus scrofa [Reaction:R-SSC-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Sus scrofa [Reaction:R-SSC-3788725] Cdh1:APC/C complex binds EHMT1:EHMT2 - Sus scrofa [Reaction:R-SSC-3788724] Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 - Sus scrofa [Reaction:R-SSC-3788748] EHMT1:EHMT2 methylates IL6 promoter - Sus scrofa [Reaction:R-SSC-3788745] EHMT1:EHMT2 methylates IL8 promoter - Sus scrofa [Reaction:R-SSC-198746] ERK1/2/5 activate RSK1/2/3 - Sus scrofa [Reaction:R-SSC-3857329] MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB - Sus scrofa [Reaction:R-SSC-3857336] CEBPB homodimerization - Sus scrofa [Reaction:R-SSC-182594] Association of INK4 family proteins with CDK4/6 - Sus scrofa
inferredFrom	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Senescence-Associated Secretory Phenotype (SASP)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2559582
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-SSC-453279] Mitotic G1 phase and G1/S transition [Pathway:R-SSC-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-SSC-2559580] Oxidative Stress Induced Senescence
(inferredTo)	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)

© 2026 Reactome

Cite Us!