Reactome | Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>

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Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
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catalystActivity	[CatalystActivity:10147603] ubiquitin-ubiquitin ligase activity of p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10147605
displayName	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
eventOf	[Pathway:R-RNO-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Homo sapiens
input	[Polymer:R-RNO-450152] K63polyUb [cytosol] [Complex:R-RNO-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] [Complex:R-RNO-202463] UBE2N:UBE2V1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
output	[Complex:R-RNO-975172] K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] [CandidateSet:R-RNO-450819] p-Pellino-1,2,(3) [cytosol] [Complex:R-RNO-202463] UBE2N:UBE2V1 [cytosol]
precedingEvent	[Reaction:R-RNO-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-975122
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-RNO-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
(inferredTo)	[Reaction:R-HSA-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation

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Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation Show undefined attributes

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Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
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