Reactome | p-Pellino-1,2,(3) [cytosol]

Schema > CandidateSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] - Rattus norvegicus [Complex:R-RNO-451410] IRAK4: p-Pellino-1,2,3 [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation - Rattus norvegicus [Reaction:R-RNO-937044] Pellino binds hp-IRAK1:TRAF6 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10141927
displayName	p-Pellino-1,2,(3) [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-RNO-450806] phospho-p-PELI3 [cytosol] - Rattus norvegicus
hasMember	[EntityWithAccessionedSequence:R-RNO-450815] phospho-p-PELI1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-450825] phospho-Peli2 [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[CandidateSet:R-HSA-450819] p-Pellino-1,2,(3) [cytosol] - Homo sapiens
maxDepth	2
name	p-Pellino-1,2,(3)
producedByEvent	[Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Rattus norvegicus [BlackBoxEvent:R-RNO-8948066] K63polyUb-IRAK1 dissociates - Rattus norvegicus [Reaction:R-RNO-937050] Pellino ubiquitinates hp-IRAK1 - Rattus norvegicus
schemaClass	CandidateSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-450819

(output)	[Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation [BlackBoxEvent:R-RNO-8948066] K63polyUb-IRAK1 dissociates [Reaction:R-RNO-937050] Pellino ubiquitinates hp-IRAK1
(activeUnit)	[CatalystActivity:10147603] ubiquitin-ubiquitin ligase activity of p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] [CatalystActivity:10146212] ubiquitin-ubiquitin ligase activity of p-Pellino:hp-IRAK1:TRAF6 [plasma membrane]
(input)	[Reaction:R-RNO-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation [Reaction:R-RNO-937044] Pellino binds hp-IRAK1:TRAF6
(hasComponent)	[Complex:R-RNO-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] [Complex:R-RNO-451410] IRAK4: p-Pellino-1,2,3 [cytosol] [Complex:R-RNO-8948061] K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] [Complex:R-RNO-451411] hp-IRAK1: p-Pellino-1,2,(3) [cytosol] [Complex:R-RNO-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane]
(inferredTo)	[CandidateSet:R-HSA-450819] p-Pellino-1,2,(3) [cytosol]

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