Reactome | K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane]

Schema > Complex > Entries

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-RNO-975121] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10147592
displayName	K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane]
hasComponent	[EntityWithAccessionedSequence:R-RNO-975112] phospho-K63polyUb-hp-IRAK1 [endosome membrane] [EntityWithAccessionedSequence:R-RNO-450272] Traf6 [endosome membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-975172] K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] - Homo sapiens
maxDepth	2
name	K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6
producedByEvent	[Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-975172
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
(output)	[Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(hasComponent)	[Complex:R-RNO-975121] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane]
(inferredTo)	[Complex:R-HSA-975172] K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane]

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