Reactome | K63polyUb [cytosol]

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K63polyUb [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] - Rattus norvegicus [Complex:R-RNO-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] - Rattus norvegicus [Complex:R-RNO-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] - Rattus norvegicus [Complex:R-RNO-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] - Rattus norvegicus [Complex:R-RNO-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] - Rattus norvegicus [Complex:R-RNO-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Rattus norvegicus [Complex:R-RNO-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Rattus norvegicus [Complex:R-RNO-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Rattus norvegicus [Complex:R-RNO-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] - Rattus norvegicus [Complex:R-RNO-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-741386] RIP2 induces K63-linked ubiquitination of NEMO - Rattus norvegicus [Reaction:R-RNO-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Rattus norvegicus [Reaction:R-RNO-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Rattus norvegicus [Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Rattus norvegicus [BlackBoxEvent:R-RNO-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Rattus norvegicus [Reaction:R-RNO-5688797] ATXN3 family cleave Ub chains - Rattus norvegicus [Reaction:R-RNO-5691431] PSMD14 cleaves K63-linked ubiquitin - Rattus norvegicus [BlackBoxEvent:R-RNO-5696547] STAMBPL1 is a deubiquitinase - Rattus norvegicus [Reaction:R-RNO-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Rattus norvegicus [Reaction:R-RNO-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Rattus norvegicus [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated - Rattus norvegicus [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated - Rattus norvegicus [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated - Rattus norvegicus [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated - Rattus norvegicus [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated - Rattus norvegicus [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated - Rattus norvegicus [Reaction:R-RNO-937050] Pellino ubiquitinates hp-IRAK1 - Rattus norvegicus [Reaction:R-RNO-937050] Pellino ubiquitinates hp-IRAK1 - Rattus norvegicus [BlackBoxEvent:R-RNO-2730904] Auto-ubiquitination of TRAF6 - Rattus norvegicus [BlackBoxEvent:R-RNO-5607756] TRAF6 oligomer autoubiquitinates - Rattus norvegicus [Reaction:R-RNO-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Rattus norvegicus [Reaction:R-RNO-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Rattus norvegicus [Reaction:R-RNO-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Rattus norvegicus [BlackBoxEvent:R-RNO-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Rattus norvegicus [Reaction:R-RNO-9931430] MIB2-mediated K63-ubiquitination of CD274 - Rattus norvegicus [Reaction:R-RNO-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Rattus norvegicus [Reaction:R-RNO-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Rattus norvegicus [Reaction:R-RNO-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Rattus norvegicus [Reaction:R-RNO-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Rattus norvegicus [Reaction:R-RNO-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Rattus norvegicus [Reaction:R-RNO-202453] Auto-ubiquitination of TRAF6 - Rattus norvegicus [Reaction:R-RNO-202453] Auto-ubiquitination of TRAF6 - Rattus norvegicus [Reaction:R-RNO-202453] Auto-ubiquitination of TRAF6 - Rattus norvegicus [BlackBoxEvent:R-RNO-5607757] K63polyUb-TRAF6 ubiquitinates TAK1 - Rattus norvegicus [BlackBoxEvent:R-RNO-202534] Ubiquitination of NEMO by TRAF6 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10117453
displayName	K63polyUb [cytosol]
inDisease	false
inferredFrom	[Polymer:R-HSA-450152] K63polyUb [cytosol] - Homo sapiens [Polymer:R-HSA-6783297] Short K63polyUb [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-RNO-5689096] PolyUb [cytosol] - Rattus norvegicus
name	K63polyUb
producedByEvent	[Reaction:R-RNO-5688797] ATXN3 family cleave Ub chains - Rattus norvegicus [Polymerisation:R-RNO-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Rattus norvegicus [Polymerisation:R-RNO-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Rattus norvegicus [Polymerisation:R-RNO-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Rattus norvegicus [Reaction:R-RNO-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 - Rattus norvegicus [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Rattus norvegicus [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Rattus norvegicus [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Rattus norvegicus [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Rattus norvegicus [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Rattus norvegicus [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 - Rattus norvegicus [Reaction:R-RNO-741411] CYLD deubiquitinates NEMO - Rattus norvegicus [Reaction:R-RNO-5691439] BRISC complex deubiquitinates NLRP3 - Rattus norvegicus [Reaction:R-RNO-6781814] USP19 deubiquitinates RNF123 - Rattus norvegicus [Reaction:R-RNO-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Rattus norvegicus [Reaction:R-RNO-6781779] USP13 deubiquitinates BECN1,USP10 - Rattus norvegicus [Reaction:R-RNO-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 - Rattus norvegicus
repeatedUnit	[DefinedSet:R-RNO-450143] K63-Ub [cytosol]
schemaClass	Polymer
species	[Species:48895] Rattus norvegicus
stId	R-RNO-450152
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] [Complex:R-RNO-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] [Complex:R-RNO-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] [Complex:R-RNO-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] [Complex:R-RNO-9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] [Complex:R-RNO-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] [Complex:R-RNO-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] [Complex:R-RNO-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] [Complex:R-RNO-8948017] UBE2N:UBE2V1:K63polyUb [cytosol] [Complex:R-RNO-975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] [Complex:R-RNO-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane]
(input)	[Reaction:R-RNO-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Reaction:R-RNO-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) [Reaction:R-RNO-688137] RIP2 is K63 polyubiquitinated [Reaction:R-RNO-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Reaction:R-RNO-741386] RIP2 induces K63-linked ubiquitination of NEMO [Reaction:R-RNO-937050] Pellino ubiquitinates hp-IRAK1 [Reaction:R-RNO-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex [BlackBoxEvent:R-RNO-2730904] Auto-ubiquitination of TRAF6 [Reaction:R-RNO-202453] Auto-ubiquitination of TRAF6 [BlackBoxEvent:R-RNO-5607756] TRAF6 oligomer autoubiquitinates [BlackBoxEvent:R-RNO-5607757] K63polyUb-TRAF6 ubiquitinates TAK1 [BlackBoxEvent:R-RNO-202534] Ubiquitination of NEMO by TRAF6 [Reaction:R-RNO-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation [BlackBoxEvent:R-RNO-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 [Reaction:R-RNO-9931430] MIB2-mediated K63-ubiquitination of CD274 [BlackBoxEvent:R-RNO-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK [Reaction:R-RNO-5688797] ATXN3 family cleave Ub chains [Reaction:R-RNO-5691431] PSMD14 cleaves K63-linked ubiquitin [BlackBoxEvent:R-RNO-5696547] STAMBPL1 is a deubiquitinase
(output)	[Reaction:R-RNO-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 [Polymerisation:R-RNO-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains [Polymerisation:R-RNO-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation [Reaction:R-RNO-688136] TNFAIP3 (A20) deubiquitinates RIP2 [Reaction:R-RNO-741411] CYLD deubiquitinates NEMO [Polymerisation:R-RNO-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Reaction:R-RNO-5688797] ATXN3 family cleave Ub chains [Reaction:R-RNO-5691439] BRISC complex deubiquitinates NLRP3 [Reaction:R-RNO-6781814] USP19 deubiquitinates RNF123 [Reaction:R-RNO-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [Reaction:R-RNO-6781779] USP13 deubiquitinates BECN1,USP10 [Reaction:R-RNO-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
(inferredTo)	[Polymer:R-HSA-450152] K63polyUb [cytosol] [Polymer:R-HSA-6783297] Short K63polyUb [cytosol]
(hasMember)	[DefinedSet:R-RNO-5689096] PolyUb [cytosol]

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