Reactome | NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9

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NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10147596
displayName	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
eventOf	[Pathway:R-RNO-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 - Homo sapiens
input	[Complex:R-RNO-168113] CHUK:IKBKB:IKBKG [cytosol] [Complex:R-RNO-975172] K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
output	[Complex:R-RNO-975121] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane]
precedingEvent	[Reaction:R-RNO-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-975119
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
(inferredTo)	[Reaction:R-HSA-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9

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