Reactome | Casp8 [cytosol]

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Casp8 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] - Rattus norvegicus [Complex:R-RNO-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] - Rattus norvegicus [Complex:R-RNO-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Rattus norvegicus [Complex:R-RNO-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-141156] TRAIL-mediated dimerization of procaspase-8 - Rattus norvegicus [Reaction:R-RNO-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 - Rattus norvegicus [Reaction:R-RNO-9823816] OPTN binds CASP8 - Rattus norvegicus [Reaction:R-RNO-73945] FAS-mediated dimerization of procaspase-8 - Rattus norvegicus [Reaction:R-RNO-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Rattus norvegicus [Reaction:R-RNO-141159] TNF-mediated dimerization of procaspase-8 - Rattus norvegicus [Reaction:R-RNO-2562541] TLR4-induced ripoptosome assembly - Rattus norvegicus [Reaction:R-RNO-2562541] TLR4-induced ripoptosome assembly - Rattus norvegicus [Reaction:R-RNO-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10107923
displayName	Casp8 [cytosol]
endCoordinate	479
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-RNO-622416] Long prodomain caspases [cytosol] - Rattus norvegicus
name	Casp8 CASP8(1-479) Q9JHX4
referenceEntity	[ReferenceGeneProduct:uniprot:Q9JHX4] UniProt:Q9JHX4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-57031
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-9823816] OPTN binds CASP8 [Reaction:R-RNO-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [Reaction:R-RNO-73945] FAS-mediated dimerization of procaspase-8 [Reaction:R-RNO-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Reaction:R-RNO-141156] TRAIL-mediated dimerization of procaspase-8 [Reaction:R-RNO-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 [Reaction:R-RNO-141159] TNF-mediated dimerization of procaspase-8 [Reaction:R-RNO-2562541] TLR4-induced ripoptosome assembly
(hasComponent)	[Complex:R-RNO-3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] [Complex:R-RNO-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] [Complex:R-RNO-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Complex:R-RNO-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] [Complex:R-RNO-5637468] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] [Complex:R-RNO-9823815] OPTN:CASP8 [cytosol] [Complex:R-RNO-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Complex:R-RNO-3465443] DISC:procaspase-8 [plasma membrane] [Complex:R-RNO-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-RNO-2671817] procaspase-8 dimer [cytosol]
(activeUnit)	[CatalystActivity:10167547] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
(hasMember)	[CandidateSet:R-RNO-622416] Long prodomain caspases [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol]

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